Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12219410.23868/201906013ArticlesСтатьиResearch ArticleCURRENT STATE OF TISSUE ENGINEERING FOR CARTILAGE REGENERATIONСОВРЕМЕННОЕ СОСТОЯНИЕ ТКАНЕВОЙ ИНЖЕНЕРИИ ДЛЯ ВОССТАНОВЛЕНИЯ ХРЯЩЕВОЙ ТКАНИBeketovE. EБекетовЕ. Еbeketov.ee@yandex.ruIsaevaE. VИсаеваЕ. ВShegayP. VШегайП. ВIvanovS. AИвановС. АKaprinA. DКапринА. ДA. Tsyb Medical Radiological Research Center, the branch of the National Medical Research Radiological CenterМедицинский радиологический научный центр им. А.Ф. Цыба - филиал Национального медицинского исследовательского центра радиологииNational Medical Research Radiological Center of the Ministry of Health of the Russian FederationНациональный медицинский исследовательский центр радиологии15062019142VOL 14, NO2 (2019)ТОМ 14, №2 (2019)122016012023Copyright ©; 2019, Eco-VectorCopyright ©; 2019, Эко-Вектор2019Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/122194

The development of biomedical cell products for damaged cartilage recovery is an important direction of regenerative medicine. The review examines the main issues related to biodegradable tissue scaffold and hydrogel properties: selection of appropriate biomaterials, cells loaded and other supplements that could provide the best conditions for cartilage recovery. The results of in vitro and in vivo studies, as well as clinical trials registered at the National Institutes of Health database (ClinicalTrials.gov), are considered.

Создание биомедицинских клеточных продуктов для восстановления хрящевой ткани - актуальное направление регенеративной медицины. В обзоре описаны основные аспекты, связанные с подбором оптимальных материалов биодеградируемых носителей и гидрогелей, инкорпорированных в них клеток и других компонентов, обеспечивающих наилучшие условия для восстановления хрящевой ткани. рассмотрены результаты исследований in vitro и in vivo, а также клинические испытания, зарегистрированные в международном реестре Национальных институтов здравоохранения сША (ClinicalTrials.gov).

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