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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Genes &amp; Cells</journal-id><journal-title-group><journal-title xml:lang="en">Genes &amp; Cells</journal-title><trans-title-group xml:lang="ru"><trans-title>Гены и Клетки</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Genes and Cells</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-1829</issn><issn publication-format="electronic">2500-2562</issn><publisher><publisher-name xml:lang="en">Human Stem Cells Institute</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">122054</article-id><article-id pub-id-type="doi">10.23868/202003008</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Osteogenesis in epitelial tumors on the example of a pilomatricomas</article-title><trans-title-group xml:lang="ru"><trans-title>К вопросу об остеогенезе в эпителиальных опухолях на примере пиломатриком</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Deev</surname><given-names>R. V</given-names></name><name xml:lang="ru"><surname>Деев</surname><given-names>Р. В</given-names></name></name-alternatives><email>romdey@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Plaksa</surname><given-names>I. L</given-names></name><name xml:lang="ru"><surname>Плакса</surname><given-names>И. Л</given-names></name></name-alternatives><email>romdey@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Baranich</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Баранич</surname><given-names>А. В</given-names></name></name-alternatives><email>romdey@gmail.com</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shcherbakova</surname><given-names>E. V</given-names></name><name xml:lang="ru"><surname>Щербакова</surname><given-names>Е. В</given-names></name></name-alternatives><email>romdey@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vinogradov</surname><given-names>I. I</given-names></name><name xml:lang="ru"><surname>Виноградов</surname><given-names>И. И</given-names></name></name-alternatives><email>romdey@gmail.com</email><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Human Stem Cell Institute</institution></aff><aff><institution xml:lang="ru">Институт стволовых клеток человека</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.I. Mechnikov North-Western State Medical University</institution></aff><aff><institution xml:lang="ru">Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Moscow City Oncology Hospital № 62</institution></aff><aff><institution xml:lang="ru">Московская городская онкологическая больница № 62</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">I.P. Pavlov Ryazan State Medical University</institution></aff><aff><institution xml:lang="ru">Рязанский государственный медицинский университет им. И.П. Павлова</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Ryazan Regional Clinical Oncology Center</institution></aff><aff><institution xml:lang="ru">Областной клинический онкологический диспансер</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2020</year></pub-date><volume>15</volume><issue>1</issue><issue-title xml:lang="en">VOL 15, NO1 (2020)</issue-title><issue-title xml:lang="ru">ТОМ 15, №1 (2020)</issue-title><fpage>60</fpage><lpage>65</lpage><history><date date-type="received" iso-8601-date="2023-01-16"><day>16</day><month>01</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, Эко-Вектор</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://genescells.ru/2313-1829/article/view/122054">https://genescells.ru/2313-1829/article/view/122054</self-uri><abstract xml:lang="en"><p>Heterotopic osteogenesis (HO) is the process of formation of typical bone tissue in a place in the body where this tissue normally does not develop. HO can be the outcome of many pathological processes, for example, necrosis, the organization of hematomas and primary tuberculous affect, and also develop in tumors of various histogenesis. This may be an example of the mutual induction of tissue development in an adult organism. Pilomatricoma (epithelioma of Malherbe) is a rare benign tumor, accounting for 0,2% of all skin neoplasms, developing from the hair follicle epithelium. In rare cases, foci of HO can be detected in the tumor structure. 43 cases pilomatricomas were analyzed by, in 3 (7%) of which bone tissue was detected. Histological and immunohistochemical studies and clinical morphological analysis were performed.</p></abstract><trans-abstract xml:lang="ru"><p>Гетеротопический остеогенез (ГО) - это процесс формирования типичной (в патоморфологическом смысле) костной ткани в таком месте организма, где в норме эта ткань не развивается. ГО может стать исходом каких-либо патологических процессов, например, организации некроза и гематом, первичного туберкулезного аффекта, а также сформироваться в опухолях различного гистогенеза. Последние случаи представляют помимо практического и теоретический интерес, как пример явления взаимоиндукции тканей во взрослом организме. Пиломатрикома (эпителиома Малерба) - это редкая доброкачественная опухоль, составляющая 0,2% от всех новообразований кожи, развивающаяся из эпителия волосяного фолликула. В редких случаях в структуре опухоли могут быть обнаружены очаги ГО. Проанализировано 43 случая пиломатриком, в 3 (7%) из которых обнаружена костная ткань. Проведены гистологические и иммуногистохимическое исследования и клинико-морфологический анализ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Malherbe epithelioma</kwd><kwd>pilomatrixoma</kwd><kwd>pilomatri-coma</kwd><kwd>heterotopic osteogenesis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эпителиома Малерба</kwd><kwd>пиломатрикома</kwd><kwd>пиломатриксома</kwd><kwd>гетеротопический остеогенез</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Фриденштейн А.Я. Г истологический анализ индуцированного остеогенеза. Дис. ...доктора мед. наук. М., 1959</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Davies O.G., Grover L.M., Eisenstein N. et al. Identifying the cellular mechanisms leading to heterotopic ossification. Calcif. Tissue Int. 2015; 97: 432-44.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Conlin Ph.A., Jimenez-Quintero L.P., Rapini R.P. Osteomas of the Skin: Clinicopathologic Review of 74 Cases. Am. J. Dermatopathol. 2002; 24(6): 479-83.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Reardon M.J., Tillou A., Mody D.R., Reardon P.R. Heterotopic calcification in abdominal wounds. Am. J. Surg. 1997; 173(2): 145-7.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Mohler E.R. 3rd, Gannon F., Reynolds C. et al. Bone formation and inflammation in cardiac valves. Circulation 2001; 102: 1522-28.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Деев Р.В., Берсенев А.В. Роль стволовых стромальных (мезенхимальных) клеток в формировании гетеротопических оссификатов. Клеточная трансплантология и тканевая инженерия 2005; 1: 46-8.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Dukes C.E. Ossification in rectal cancer. Proc. R. Soc. Med. 1939; 32: 1489-94.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Ansari M.Q., Sachs I.L., Max E., Alpert L.C. Heterotopic bone formation in rectal carcinoma. Case report and literature review. Dig. Dis. Sci. 1992; 37: 1624-9.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Kuroda N., liyama T., Moriki T. et al. Chromophobe renal cell carcinoma with focal papillary configuration, nuclear basaloid arrangement and stromal osseous metaplasia containing fatty bone marrow element. Histopathology 2005; 46: 712-3.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Levy J., Ilsar M., Deckel Y. et al. Eyelid pilomatrixoma: a description of 16 cases and a review of the literature. Surv. Ophthalmol. 2008; 53(5): 526-35.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours. IARC Press; Lyons, 2018: 153-5.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Le C., Bedocs P.M. Calcifying Epithelioma of Malherbe. https:// www.ncbi.nlm.nih.gov/books/NBK493165/.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Papadakis M., de Bree E., Floros N. et al. Pilomatrix carcinoma: More malignant biological behavior than was considered in the past. Mol. Clin. Oncol. 2017; 6(3): 415-8.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Pirouzmanesh A., Reinisch J.F., Gonzalez-Gomez I. et al. Pilomatrixoma: a review of 346 cases. Plast. Reconstr. Surg. 2003; 112(7): 1784-9.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Kaddu S., Soyer H.P., Hodl S. et al. Morphological stages of pilomatri-coma. Am. J. Dermatopathol. 1996; 18: 333-8.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Jones C.D., Ho W., Robertson B.F. et al. Pilomatrixoma. Am. J. Dermatopathology 2018; 40(9): 631-41.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Ioannidis O., Stavrakis T., Cheva A. et al. Forearm Pilomatricoma with Extensive Ossification. Adv. Med. Sci. 2010; 55(2): 340-2.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Richet C., Mazereeuw-Hautier J. Childhood pilomatricomas: Associated anomalies. Pediatric Dermatol. 2018; 35: 548-51.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Malherbe A. Recherches sur l'epitheliome calcifie des glandes sebacees. Paris; 1882.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Фридненштейн А.Я. Экспериментальное внескелетное костеобразование. М.: Медицинская литература, 1963</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Фриденштейн А.Я, Лалыкина К.С. Индукция костной ткани и остеогенные клетки предшественники. М.: Медицина, 1973</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Данилов Р.К. Общие принципы клеточной организации, развития и классификации тканей. В кн.: Руководство по гистологии. Под ред. Р.К. Данилова. - 2е изд. СПб.: СпецЛит, 2011; Т. 1: 98-123</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Urist M.R., Basil S.S. Bone Morphogenetic Protein. J. Dental Res. 1971; 50(6): 1392-406.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Grgurevic L., Pecina, M., Vukicevic S. Marshall R. Urist and the discovery of bone morphogenetic proteins. Int. Orth. 2017; 41(5): 1065-9.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Sampath T.K., Reddi A.H. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. PNAS USA 1981; 78(12): 7599-603.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Chen D., Zhao M., Mundy G.R. Bone morphogenetic proteins. Growth Factors 2001; 22(4): 233-41.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Botchkarev V.A. Bone morphogenetic proteins and their antagonists in skin and hair follicle biology. Invest. Dermatol. 2003; 120(1): 36-47.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Botchkarev V., Sharov A.A. BMP signaling in the control of skin development and hair follicle growth. Different. 2004; 72(9-10): 512-26.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Khuraijam B., Sobti P., Shangpliang D., Khurana N. Extramedullary Haematopoiesis in a Case of Pilomatricoma. J. Clin. Diagnost. Res. 2016; 10(6): ED17-8.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Jaiswal A.A., Garg A.K., Membally R. et al. Ossifying pilomatrixoma with marrow formation of the left cheek region - Case report with review of literature. Egyptian J. Ear, Nose, Throat and Allied Sci. 2015; 16(2): 193-9.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Mieno H., Kuroda K. Tajima S. Bone morphogenetic protein-mediated type II collagen expression in pilomatricoma and cutaneous mixed tumor. J. Cutan. Pathol. 2005; 32(3): 206-11.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Mieno H., Kuroda K., Shinkai H. et al. Type II Collagen Accumulation in Overlying Dermo-Epidermal Junction of Pilomatricoma Is Mediated by Bone Morphogenetic Protein 2 and 4. J. Inv. Dermatol. 2004; 122(4): 878-84.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Singh V., Sinha R.J., Sankhwar S.N. et al. Heterotopic bone formation in renal cell carcinoma: A diagnostic challenge. Indian J. Cancer 2008; 45: 126-7.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Yamasaki M., Nomura T., Mimata H. et al. Involvement of bone morphogenetic protein 2 in ossification of renal cell carcinoma. J. Urol. 2004; 172: 475-6.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Agarwal S., Bohara S., Jha R. et al. Clear cell renal cell carcinoma with osseous metaplasia: Rare case report. J. Can. Res. Ther. 2015; 11: 1039. doi: 10.4103/0973-1482.146109.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Ishida T., Abe S., Miki Y., Imamura T. Intraosseous pilomatricoma: a possible rare skeletal manifestation of Gardner syndrome. Skeletal Radiol. 2007; 36(7): 693-8.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Burgdorf W., Nasemann T. Cutaneous Osteomas: A Clinical and Histopathologic Review. Arch. Dermatol. Res. 1977; 260(2), 121-35.</mixed-citation></ref></ref-list></back></article>
