Genes & CellsGenes & Cells2313-18292500-2562Human Stem Cells Institute12199710.23868/202110012Research ArticleInvestigation of HLA-DRB1 and IL28 gene polymorphism in patients with varying severity of COVID-19 infectionKolyubaevaS. N-KondratenkoA. A-AlkhazheK.-KryukovE. V-ЧирскийВ. С-KachnovV. A-GlushakovR. I-SveklinaT. S-MyakoshinaL. A-TyuryupovM. S-NeronovaE. G-EliseevaM. I-S.M. Kirov Military Medical AcademySt. Petersburg State UniversityA.M. Nikiforov Russian Centre of Emergency and Radiation Medicine15092021163869016012023Copyright © 2021, Eco-Vector2021The work analyzed the polymorphisms of the HLA-DRB1 and IL28 genes in 100 patients who underwent COVID-19 with the development of infection with varying degrees of severity. To a mild degree of severity were patients without complications in the form of infectious pneumonate, to moderate and severe degrees - with the development of pneumonate with varying degrees of lung damage. In general, the distribution of alleles in patients with COVID-19 did not differ from the distribution of average values in Russia. However, the HLA-DRB1 *01 и *07 alleles were more common. Comparison of the frequency of HLA-DRB1 alleles in patients with COVID-19 with varying severity revealed more common alleles of *13 and *07 in the severety severe group. However, with OR of 3.2 and 1.8, their confidence intervals (CL) were in the range of 0.9-9.8 and 0.7-4.5 respectively. At severe severity, the presence of homozigotic variants of allele *07 is noted. (Fisher exact test, r.0.04). As for the IL28B gene, no statistically significant differences from the control group were found.patientsseverity of the diseaseinfectious pneumonitpolymorphism of genes HLA-DRB1 and IL28Ballelesновая коронавирусная инфекциястепень тяжести заболеванияинфекционный пневмонитполиморфизм генов HLA-DRB1 и IL28Bаллели[Ganna A., Vadgama N., Chaudhary K. et al. 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