Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12197510.23868/202012007ArticlesСтатьиResearch ArticleStudy of the RS2910164 polymorphic variant of MIR-146A microRNA gene in patients with primary osteoporosisИзучение полиморфного варианта RS2910164 гена микроРНК MIR-146А у пациентов с первичным остеопорозомYalaevB. IЯлаевБ. Иyalaev.bulat@yandex.ruKhusainovaR. IХусаиноваР. Иritakh@mail.ruInstitute of Biochemistry and Genetics - subdivision of the Ufa Federal Research Centre of the RASИнститут биохимии и генетики - обособленное структурное подразделение Уфимского федерального исследовательского центра РАН10122020154VOL 15, NO4 (2020)ТОМ 15, №4 (2020)404516012023Copyright ©; 2020, Eco-VectorCopyright ©; 2020, Эко-Вектор2020Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/121975

MiRNAs, known as the family of short non-coding RNAs, are key repressors of gene expression and play an important role in the regulation of osteogenesis, interact with signaling molecules of bone remodeling, and control the processes of differentiation of bone cells. A study of the polymorphic variant rs2910164 (n. 303C>G) of the microRNA gene (miR-146a) and an assessment of its role in the formation of the risk of osteoporetic fractures and low bone mineral density (BMD) in a sample of postmenopausal women and men over 45 years of age was conducted. The C allele was found to be associated with a low level of bone mineral density in the lumbar spine in women. There were no significant associations of the studied locus with osteoporotic fractures in General and their separate localities in men and women, with a low level of BMD in General and various localities in men.

МикроРНК (miRNAs), известные как семейство коротких некодирующих РНК, являются ключевыми репрессорами экспрессии генов и играют важную роль в регуляции остеогенеза, взаимодействуют с сигнальными молекулами костного ремоделирования и контролируют процессы дифференцировки клеток костной ткани. Цель работы: для поиска молекулярно-генетических маркеров остеопороза оценить роль полиморфного варианта rs2910164 (n. 303C>G) гена микроРНК (miR-146a) в возникновении риска остеопоретических переломов и понижении уровня минеральной плотности костной ткани в выборке женщин в постменопаузе и мужчин старше 45 лет. Обнаружено, что аллель *С ассоциирован с низким уровнем минеральной плотности костной ткани в поясничном отделе позвоночника у женщин. Не выявлены значимые ассоциации изученного локуса с остеопоретическими переломами в целом и их отдельными локализациями у мужчин и женщин, а также с низким уровнем минеральной плотности костной ткани в целом и в различных отделах скелета у мужчин.

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