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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Genes &amp; Cells</journal-id><journal-title-group><journal-title xml:lang="en">Genes &amp; Cells</journal-title><trans-title-group xml:lang="ru"><trans-title>Гены и Клетки</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Genes and Cells</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-1829</issn><issn publication-format="electronic">2500-2562</issn><publisher><publisher-name xml:lang="en">Human Stem Cells Institute</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">121906</article-id><article-id pub-id-type="doi">10.23868/202205003</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Elastic ear cartilage of Acomys mice is recovering after injury</article-title><trans-title-group xml:lang="ru"><trans-title>У мышей рода Acomys после травмы восстанавливается эластический хрящ ушной раковины</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bilyalov</surname><given-names>A. I</given-names></name><name xml:lang="ru"><surname>Билялов</surname><given-names>А. И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Filimoshina</surname><given-names>D. D</given-names></name><name xml:lang="ru"><surname>Филимошина</surname><given-names>Д. Д</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Filatov</surname><given-names>N. S</given-names></name><name xml:lang="ru"><surname>Филатов</surname><given-names>Н. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bilyalova</surname><given-names>A. A</given-names></name><name xml:lang="ru"><surname>Билялова</surname><given-names>А. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Titova</surname><given-names>A. A</given-names></name><name xml:lang="ru"><surname>Титова</surname><given-names>А. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gataullina</surname><given-names>L. R</given-names></name><name xml:lang="ru"><surname>Гатауллинна</surname><given-names>Л. Р</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Plushkina</surname><given-names>A. S</given-names></name><name xml:lang="ru"><surname>Плюшкина</surname><given-names>А. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shagimardanova</surname><given-names>E. I</given-names></name><name xml:lang="ru"><surname>Шагимарданова</surname><given-names>Е. И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Deev</surname><given-names>R. V</given-names></name><name xml:lang="ru"><surname>Деев</surname><given-names>Р. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kiyasov</surname><given-names>A. P</given-names></name><name xml:lang="ru"><surname>Киясов</surname><given-names>А. П</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kozlova</surname><given-names>O. S</given-names></name><name xml:lang="ru"><surname>Козлова</surname><given-names>О. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nesmelov</surname><given-names>A. A</given-names></name><name xml:lang="ru"><surname>Несмелов</surname><given-names>А. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gusev</surname><given-names>O. A</given-names></name><name xml:lang="ru"><surname>Гусев</surname><given-names>О. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan (Volga region) federal university</institution></aff><aff><institution xml:lang="ru">Казанский (Приволжский) федеральный университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The Loginov Moscow Clinical Scientific Center Under the Health Department of Moscow</institution></aff><aff><institution xml:lang="ru">Московский клинический научный центр им. А.С. Логинова ДЗМ</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">I.I. Mechnikov North-Western State Medical University</institution></aff><aff><institution xml:lang="ru">Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Juntendo University</institution></aff><aff><institution xml:lang="ru">Университет Джунтендо</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Endocrinology Research Centre</institution></aff><aff><institution xml:lang="ru">НМИЦ эндокринологии Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2022</year></pub-date><volume>17</volume><issue>1</issue><issue-title xml:lang="en">VOL 17, NO1 (2022)</issue-title><issue-title xml:lang="ru">ТОМ 17, №1 (2022)</issue-title><fpage>42</fpage><lpage>47</lpage><history><date date-type="received" iso-8601-date="2023-01-16"><day>16</day><month>01</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Эко-Вектор</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-03-15"/></permissions><self-uri xlink:href="https://genescells.ru/2313-1829/article/view/121906">https://genescells.ru/2313-1829/article/view/121906</self-uri><abstract xml:lang="en"><p>The article presents data on the regeneration of the auricle tissues of Acomys cahirinus mice (n=12) and Balb/c mice (n=12). Two experimental models were used: a full-thickness perforated defect with a diameter of 3 mm and subtotal removal of the auricle. Macrophotography and histological examination using general histological stains and detection of elastic fibers were performed after 2, 5, 15, 21, 30, 60, 90, and 120 days. It was found that regeneration in Acomys is more pronounced, which manifested itself in the complete elimination of the defect by 30-60 days in contrast to the control (Balb/c). A feature of this was less pronounced post-traumatic inflammation in Acomys mice. It was established the growth of a full-fledged auricle in case of its surgical removal. An important feature of regeneration in this case is the development of new cartilage tissue both from the edges of the original cartilage and developed in the form of separate islands of cartilage tissue. The newly formed cartilage was characterized by high cel-lularity, a smaller volume of the matrix, in the structure of which elastic fibers were formed. However, it should be noted that within 30-60 days. the recovery process, apparently, is not completed, the formed tissue regenerate enters the remodeling phase.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлены данные о регенерации тканей ушной раковины мышей Acomys cahirinus (n=12), и мышей линии Balb/c (n=12). Применены две экспериментальные модели: полнослойный дырчатый дефект диаметром 3 мм и субтотальное удаление ушной раковины. Макрофотографирование и гистологическое исследование с применением общегистологических окрасок и выявлением эластических волокон осуществляли через 2, 5, 15, 21, 30, 60, 90 и 120 сут. Установлено, что в обоих моделях регенерация у Acomys более выражена, что проявилось в полном устранении дефекта к 30-60 сут. в отличие от контроля (Balb/c) и развитии полноценной ушной раковины в случае ее хирургического удаления. Тканевой особенностью при этом стало менее выраженное посттравматическое воспаление у мышей Acomys. Важной особенностью регенерации при этом является развитие хрящевого регенерата, который брал свое начало как от краев отреза предсуществовавшего хряща, так развивался в виде отдельных островков хрящевой ткани. Новообразованный хрящ характеризовался высокой клеточностью, меньшим по сравнению с исходным состоянием матрикса объемом, в структуре которого формировались эластические волокна. Вместе с тем, следует отметить, что в течение 30-60 сут. процесс восстановления, по-видимому, не завершен, образованный тканевый регенерат вступает в фазу ремоделирования.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Acomys</kwd><kwd>Acomys</kwd><kwd>cartilage</kwd><kwd>cartilage tissue</kwd><kwd>defect</kwd><kwd>regeneration</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хрящ</kwd><kwd>хрящевая ткань</kwd><kwd>дефект</kwd><kwd>регенерация</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Tuan R.S., Chen A.F., Klatt B.A. Cartilage regeneration. J.Am. Acad. Orthop. Surg. 2013; 21(5): 303-11.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Trengove A., Di Bella C., O'Connor A. The Challenge of Cartilage Integration: Understanding a Major Barrier to Chondral Repair. Tissue Engineer. 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