Genes & CellsGenes & Cells2313-18292500-2562Human Stem Cells Institute12187110.23868/gc121871Research ArticleNegative consequences of the phenomenon of fusion of bone marrow cellsPospelovA.redaktor@celltranspl.ru15012006111121601202316012023Copyright © 2023, Eco-Vector2023[Terada N.. Hamazaki T„ Oka M. et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002;.416[6880): 542-5.][Wang X., Willenbring H., Akkari Y. et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003; 422: 897.][Ferrari G., Cusella-De Angelis G., Coletta M. et al. Muscle regeneration by bone marrow derived myogenic progenitors. Science 1998; 279: 1528-30.][Nygren J.M., Jovinge S., Breitbach M. et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nature Med. 2004; 10: 494-501.][Alvarez-Dolado M„ Pardal R., Garcia-Verdugo J. et al. Fusion of bonemarrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003; 425: 968-73.][Abedi M„ Greer D.A., Colvin G.A. et al. Robust conversion of marrow cells to skeletal muscle with formation of marrow-derived muscle cell colonies: a multifactorial process. Exp. Hematol. 2004; 32: 426-34.][Willenbring Н., Bailey A.S., Foster M. et al. Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat. Med. 2004; 10; 7: 744-8.][Shi D„ Reinecke H., Murry C.E., Torok-Storb B. Myogenic fusion of human bone marrow stromal cells, but not hematopoietic cells. Blood 2004; 104[1): 290-4.][Ogle B.M. et al. Spontaneous fusion of cells between species yields transdifferentiation and retroviral in vivo. FASEB J. 2004; 18: 548-50.][Ogle B.M., Cascalho M„ Platt J.L. Biological implications of cell fusion. Nat. Rev. Mol. Cell Biol. 2005; 6(7): 567-75.][Lapidos K.A., Chen Y.E., Earley J.U. et al. Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle. J. Clin. Invest. 2004; 114:1577-85.][Dell'Agnola C., Wang Z., Storb R. et al. Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscula dystrophy dogs. Blood 2004; 104(13): 4311-8.][Kojima H., Fujimiya M„ Matsumura K. et al. Extrapancreatic insulinproducing cells in multiple organs in diabetes. Proc. Natl. Acad. Sol. USA 2004; 101(8): 2458-63.]