Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12167210.23868/gc121672ArticlesСтатьиSinusoidal liver cells and bone marrow cells as components of the common functional systemfor regulation of recovery morphogenesis of healthy and damaged liverСинусоидальные клетки печени и клетки костного мозгакак компоненты единой функциональной системырегуляции восстановительного морфогенезав здоровой и поврежденной печениOnischenkoN AОнищенкоН А

V.I. Shumakov Federal Research Center for Transplantology and Artificial Organs, the Ministry of Public Healthand Social Development, Moscow

ФГУ «ФНЦ Трансплантологии и искусственных органов им. акад. В.И. Шумакова»Минздравсоцразвития, Москва

LyundupA VЛюндупА В

V.I. Shumakov Federal Research Center for Transplantology and Artificial Organs, the Ministry of Public Healthand Social Development, Moscow

ФГУ «ФНЦ Трансплантологии и искусственных органов им. акад. В.И. Шумакова»Минздравсоцразвития, Москва

DeevR VДеевР В

Human Stem Cells Institute, Moscow

Институт cтволовых клеток человека, Москва

ShagidulinM YШагидулинМ Ю

V.I. Shumakov Federal Research Center for Transplantology and Artificial Organs, the Ministry of Public Healthand Social Development, Moscow

ФГУ «ФНЦ Трансплантологии и искусственных органов им. акад. В.И. Шумакова»Минздравсоцразвития, Москва

KrasheninnikovM EКрашенинниковМ Е

V.I. Shumakov Federal Research Center for Transplantology and Artificial Organs, the Ministry of Public Healthand Social Development, Moscow

ФГУ «ФНЦ Трансплантологии и искусственных органов им. акад. В.И. Шумакова»Минздравсоцразвития, Москва

V.I. Shumakov Federal Research Center for Transplantology and Artificial Organs, the Ministry of Public Healthand Social Development, MoscowФГУ «ФНЦ Трансплантологии и искусственных органов им. акад. В.И. Шумакова»Минздравсоцразвития, МоскваHuman Stem Cells Institute, MoscowИнститут cтволовых клеток человека, Москва1506201162NO2 (2011)№2 (2011)789211012023Copyright ©; 2011, Eco-VectorCopyright ©; 2011, Эко-Вектор2011Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/121672

This review presents current information about the cooperative interaction of sinusoidal liver cells and bone marrow cells at the processes of physiological, reparative and fibrosing liver regeneration. It is shown that the stem / progenitor cells of bone marrow (hematopoietic and mesenchymal stromal cells) supplement regulatory role of liver stem cells (first of all stellate cells - Ito cells), reduce the seriousness of inflammation and fibrosis, and thereby normalize the recovery process of damaged liver regeneration. It is believed that the use of mesenchymal stromal cells of bone marrow is the most future forward strategy. However, to form a final opinion on the regenerative capacity of autologous and allogeneic bone marrow cells at hepatic failure large-scale double-blind clinical trials should be carried out.

В обзоре представлены современные сведения о коо- перативном взаимодействии синусоидальных клеток пече- ни и клеток костного мозга при осуществлении процессов физиологической, репаративной и патологической (фибро- зирующей) регенерации печени. Показано, что стволовые/ прогениторные клетки костного мозга (гемопоэтические и мультипатентные мезенхимальные стромальные клетки (ММСК)) восполняют регуляционную роль стволовых кле- ток печени (прежде всего звездчатых клеток - клеток Ито), снижают выраженность процессов воспаления и фибрози- рования и тем самым модулируют процессы восстанови- тельной регенерации поврежденной печени. Полагают, что применение ММСК костного мозга яв- ляется наиболее перспективной стратегией. Однако для окончательного суждения о регенераторных возможностях аутологичных и аллогенных клеток костного мозга при пе- ченочной недостаточности необходимо проводить широко- масштабные двойные слепые клинические исследования.

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