Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12165410.23868/gc121654ArticlesСтатьиMechanisms of immunomodulatory effects of mesenchymal stem cellsМеханизмы иммуномодулирующего действиямезенхимных стволовых клетокIvanyuk,D IИванюк,Д И

V.K. Gusak Institute of Urgent and Reparative Surgery NAMS, Donetsk, Ukraine

Институт неотложной и восстановительной хирургии им. В.К. Гусака НАМНУ, Донецк, Украина

Turchin,V VТурчин,В В

V.K. Gusak Institute of Urgent and Reparative Surgery NAMS, Donetsk, Ukraine

Институт неотложной и восстановительной хирургии им. В.К. Гусака НАМНУ, Донецк, Украина

Popandonulo,A GПопандопуло,А Г

V.K. Gusak Institute of Urgent and Reparative Surgery NAMS, Donetsk, Ukraine

Институт неотложной и восстановительной хирургии им. В.К. Гусака НАМНУ, Донецк, Украина

GrinV KГриньВ К

V.K. Gusak Institute of Urgent and Reparative Surgery NAMS, Donetsk, Ukraine

Институт неотложной и восстановительной хирургии им. В.К. Гусака НАМНУ, Донецк, Украина

V.K. Gusak Institute of Urgent and Reparative Surgery NAMS, Donetsk, UkraineИнститут неотложной и восстановительной хирургии им. В.К. Гусака НАМНУ, Донецк, Украина1506201162NO2 (2011)№2 (2011)273111012023Copyright ©; 2011, Eco-VectorCopyright ©; 2011, Эко-Вектор2011Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/121654

Mesenchymal stem cells play different roles in organism and are capable to differentiate into mesenchymal cells line (osteoblasts, chondrocytes, adipocytes) and other cell lines. MSCs also can interact (directly and indirectly) with almost all cells of immune system via soluble factors and cell-contact interactions and substantially modulate immune response of an organism. MSCs can be applied in medical practice as the safe immunosuppressive agent for allogenic transplantation and for treatment of autoimmune diseases. This review deals with interactions between MSCs and immune cells and mechanisms of MSC-induced immunosuppression.

Мезенхимные стволовые клетки (МСК) выполняют раз- личные функции в организме, обладают высокой пролифе- ративной активностью и мультипотентными свойствами, то есть способны дифференцироваться в клетки мезодер- мальной (остеобласты, хондроциты, адипоциты) и других линий. МСК также способны (прямо и опосредованно) вза- имодействовать практически со всеми клетками иммунной системы посредством растворимых факторов и клеточно- контактным взаимодействием и, таким образом, в значи- тельной степени модулировать иммунный ответ организма. МСК могут найти своё применение в медицинской практике как безопасное иммуномодулирующее средство при алло- генных трансплантациях и лечении ряда аутоиммунных за- болеваний. В данном обзоре обсуждаются взаимодействие МСК с клетками иммунной системы, а также механизмы МСК-индуцированной иммуносупрессии.

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