Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12165310.23868/gc121653ArticlesСтатьиDerma fibroblasts: peculiarities of cytogenesis, histophysiology and possible clinical useФибробласты дермы: особенности цитогенеза,цитофизиологии и возможности клиническогопримененияZorinaA IЗоринаА И

Human Stem Cells Institute, Moscow

Институт стволовых клеток человека, Москва

BozoI YaБозоИ Я

S.M. Kirov Military Medical academy, Saint Petersburg

Военно-медицинская академия им. С.М. Кирова, Санкт-Петербург

ZorinV LЗоринВ Л

Human Stem Cells Institute, Moscow

Институт стволовых клеток человека, Москва

CherkasovV RЧеркасовВ Р

Human Stem Cells Institute, Moscow

Институт стволовых клеток человека, Москва

DeevR VДеевР В

Human Stem Cells Institute, Moscow

Институт стволовых клеток человека, Москва

Human Stem Cells Institute, MoscowИнститут стволовых клеток человека, МоскваS.M. Kirov Military Medical academy, Saint PetersburgВоенно-медицинская академия им. С.М. Кирова, Санкт-Петербург1506201162NO2 (2011)№2 (2011)152611012023Copyright ©; 2011, Eco-VectorCopyright ©; 2011, Эко-Вектор2011Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/121653

Gaining current experimental data a major concept on fibroblasts, the main cells of loose and dense connective tissue, undergoes significant changes moving away off classical concepts. Considering fibroblasts as a true phenotypic category we tried to address most challenging issues relating to definition of a fibroblast differon, cellular sources of their cytogenesis, histophysiology, their ageing changes in terms of influence on possible clinical use.

В свете получения современных экспериментальных данных общая концепция о фибробластах - основных клетках рыхлых и плотных волокнистых соединительных тканей - претерпевает существенные изменения, все бо- лее отдаляясь от классических представлений. В нашем обзоре, продолжая идею определения фибробластов как сугубо фенотипической категории, мы затронули наи- более проблемные вопросы, касающиеся определения дифферона фибробластов, клеточных источников их ци- тогенеза, особенностей цитофизиологии, их возрастных изменений в аспекте влияния на возможности клиниче- ского применения.

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