Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12159210.23868/gc121592ArticlesСтатьиReview ArticleProspects for the use of pluripotent stem cells derived blood components: erythropoiesisПерспективы использования плюрипотентных стволовых клеток человека для получения компонентов кровиPhilonenkoE. SФилоненкоЕ. СLagarkovaM. AЛагарьковаМ. АKiselevS. LКиселевС. ЛVavilov Institute of General Genetics of RAS, MoscowИнститут общей генетики им. Н.И. Вавилова РАН, Москва1508201382VOL 8, NO2 (2013)ТОМ 8, №2 (2013)61211012023Copyright ©; 2013, Eco-VectorCopyright ©; 2013, Эко-Вектор2013Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/121592

We review the problem of producing erythroid cells from human pluripotent stem cells. Pluripotent stem cells (embryonic stem cells, and induced pluripotent stem cells) are capable of self-renewal and differentiation into all cell types of an organism, including blood cells. Since a worldwide problem of blood donation shortage is very serious, the development of technologies to produce blood from pluripotent cells is a very modern and necessary task, which is the subject of investigations of many laboratories around the world.

С тех пор, как J.A. Thomson и соавт. (1998) впервые получили эмбриональные стволовые клетки (ЭСК) человека из внутренней клеточной массы бластоцисты [1], благодаря потенциальной способности дифференцироваться во все типы клеток организма (свойства плюрипотентности) ЭСК рассматриваются как модель для изучения процессов ранней клеточной дифференцировки и специализации. ЭСК человека могут служить также источником клеток для «регенеративной медицины», но их использование связано с рядом проблем, основная из них — проблема иммунологической совместимости. В 2006 г. K. Takahashi и S. Yamanaka получили ещё один тип плюрипотентных стволовых клеток (ПСК) — индуцированные плюрипотентные стволовые клетки (иПСК) [2]. иПСК могут быть получены для каждого пациента индивидуально, а неограниченная пролиферация позволяет производить генетические манипуляции (трансгенез и гомологичную рекомбинацию), что делает иПСК перспективным источником клеток для лечения многих заболеваний, в том числе гематологических. Проблема нехватки имму-носовместимого аллогенного материала (костного мозга, пуповинной крови, периферической крови, ге-мопоэтических стволовых клеток (ГСК)) остро стоит во всём мире [3—4], в то время как трансплантация

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