Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12159010.23868/gc121590ArticlesСтатьиReview ArticleRole of VEGF-A165 receptors in angiogenesisРоль рецепторов VEGF-A165 в ангиогенезеArutyunyanI. VАрутюнянИ. ВKananykhinaE. YКананыхинаЕ. ЮMakarovA. VМакаровА. Вesearch Center for Obstetrics, Gynecology and Perinatology MH of RF, MoscowНаучно-исследовательский институт морфологии человека РАМН, МоскваResearch Institute of Human Morphology of the RAMS, MoscowНаучный центр акушерства, гинекологии и перинатологии им. В.И. Кулакова МЗ РФ, МоскваResearch Institute of Human Morphology of the RAMS, MoscowНаучно-исследовательский институт морфологии человека РАМН, Москва1505201381VOL 8, NO1 (2013)ТОМ 8, №1 (2013)121811012023Copyright ©; 2013, Eco-VectorCopyright ©; 2013, Эко-Вектор2013Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/121590

We present an overview of current literature data on the different roles of key proangiogenic factor VEGF-A-165' receptors in angiogenesis regulation. VEGFR2 is the major effector receptor and runs intracellular cascades that provide survival, proliferation and migration of endothelial cells, the involvement of progenitor cells, the formation and maturation of new blood vessels. VEGFR1 contrary is the main regulator of the activity of VEGF-A-165, preventing excessive angiogenic response through the mechanism of negative feedback. The article also presents data on the variability of number and ratio of VEGFR1 and VEGFR2 on the surface of different cell types, providing the fine regulation of the VEGF-A-165 pathway.

Представлен обзор современных литературных данных о различной роли двух рецепторов сосудистого эндотелиального фактора роста-А165 (VEGF-A165] в регуляции ангиогенеза. VEGFR2 является основным эффекторным рецептором и запускает внутриклеточные каскады, обеспечивающие выживаемость, пролиферацию и миграцию эндотелиоцитов, привлечение прогениторных клеток, формирование и созревание новых кровеносных сосудов. VEGFR1 же является основным регулятором активности VEGF-A165, предотвращая чрезмерный ангиогенный ответ за счет механизма отрицательной обратной связи. Проанализированы данные о вариабельности количества и соотношения рецепторов VEGFR1 и VEGFR2 на поверхности различных клеточных типов, обеспечивающих тонкую регуляцию действия лиганда.

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