Genes & CellsGenes & Cells2313-18292500-2562Human Stem Cells Institute12146310.23868/gc121463Pervaya uspeshnaya popytka sozdaniya iskusstvennoy kozhi cheloveka s ispol'zovaniem embrional'nykh stvolovykh kletokGrigoryanA C-1503201051212311012023Copyright © 2010, Eco-Vector2010[Augustin М., Ermut Т., Johnsen S. Effects of autologous keratinocyte transplantation on the quality of life of patients with severe chronic leg ulcers. Dermatol. Psychosomat. 2D01; 2: 73-6.][Gallico G.G., O'Connor N.E., Compton C.C. et al. Permanent coverage of large burn wounds with autologous cultured human epithelium. N. Engl. J. Med. 1984; 311: 448-51.][Metcalfe A.D., Ferguson M.W. Bioengineering skin using mechanisms of regeneration and repair. Biomaterials 20D7; 28: 5100-13.][Alsbjorn B. In search of an ideal skin substitute. Scand. J. Plast. Reconstr. Surg. 1984; 18: 127-33.][Bongso A., Fong C-Y., Gauthaman K. Taking stem cells to the clinic: major challenges. J. Cell. Biochem. 2008; 105: 1352-Б0.][Knoepfler P.S. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 2009; 27: 1050-Б.][Odorico J.S., Kaufman D.S., Thomson J.A. Multilineage differentiation from human embryonic stem cell lines. Stem Cells 2001; 19: 193-204.][Coraux C, Hilmi C, Rouleau M. et al. Reconstituted skin from murine embryonic stem cells. Curr. Biol. 2003; 13: 849-53.][9. luchi S., Dabelsteen S., Easley K. et al. Immortalized keratinocyte lines derived from human embryonic stem cells. PNAS 2006; 103: 1792-97.][Green H., Easley K., luchi S. Marker succession during the development of keratinocytes from cultured human embryonic stem cells. PNAS 2003; 100: 15625-30.][Aberdam D. Epidermal stem cell fate: what can we learn from embryonic stem cells? Cell Tissue Res. 2008; 331: 103-37.][Metallo СМ., Ji L, de Pablo J.J., Palecek S.P. Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. Stem Cells 2008; 26: 372-80.][Byrne C, Tainsky M., Fuchs E. Programming gene expression in developing epidermis. Development 1994; 120: 2369-83.][Fuchs E. Epidermal differentiation and keratin gene expression. J. Cell. Sci. Suppl. 1993; 17: 197-208.][Turksen K., Troy T.C. Epidermal cell lineage. Biochem. Cell. Biol. 1998; 76: 889-98.][Bell E., Sher S., Hull B. et al. The reconstitution of living skin. J. Invest. Dermatol. 1983; 81: 2s-10s.]