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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Genes &amp; Cells</journal-id><journal-title-group><journal-title xml:lang="en">Genes &amp; Cells</journal-title><trans-title-group xml:lang="ru"><trans-title>Гены и Клетки</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Genes and Cells</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-1829</issn><issn publication-format="electronic">2500-2562</issn><publisher><publisher-name xml:lang="en">Human Stem Cells Institute</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">121444</article-id><article-id pub-id-type="doi">10.23868/gc121444</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Spontannaya zlokachestvennaya transformatsiya mul'tipotentnykh mezenkhimal'nykh stromal'nykh kletok v kul'ture - proiskhodit li ona v deystvitel'nosti?</article-title><trans-title-group xml:lang="ru"><trans-title>Спонтанная злокачественная трансформация мультипотентных мезенхимальных стромальных клеток в культуре - происходит ли она в действительности?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Grigoryan</surname><given-names>A S</given-names></name><name xml:lang="ru"><surname>Григорян</surname><given-names>А С</given-names></name></name-alternatives><bio xml:lang="ru"><p>ООО «Транс-Технологии», Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kruglyakov</surname><given-names>P V</given-names></name><name xml:lang="ru"><surname>Кругляков</surname><given-names>П В</given-names></name></name-alternatives><bio xml:lang="ru"><p>ООО «Транс-Технологии», Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ООО «Транс-Технологии», Санкт-Петербург</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2009-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2009</year></pub-date><volume>4</volume><issue>4</issue><issue-title xml:lang="en">NO4 (2009)</issue-title><issue-title xml:lang="ru">№4 (2009)</issue-title><fpage>78</fpage><lpage>82</lpage><history><date date-type="received" iso-8601-date="2023-01-11"><day>11</day><month>01</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2009, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2009, Эко-Вектор</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://genescells.ru/2313-1829/article/view/121444">https://genescells.ru/2313-1829/article/view/121444</self-uri><abstract xml:lang="ru"><p>В последние годы в научной литературе появились сообщения о туморогенных свойствах, приобретаемых мультипотентными мезенхимальными стромальными (ММСК) клетками при культивировании in vitro. В обзоре обсуждаются возможные механизмы этого феномена и вопрос о том, насколько правомерно говорить об опасности применения ММСК в клеточной терапии.</p></abstract><kwd-group xml:lang="ru"><kwd>мультипотентные мезенхимальные стро-мальные клетки</kwd><kwd>злокачественная трансформация</kwd><kwd>хромосомные аберрации</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Zhang X., Nakaoka Т., Nishishita Т. et al. Efficient adeno-associated virus-mediated gene expression in human placenta-derived mesenchymal cells. Microbiol. Immunol. 2003; 47: 10Э-1В.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Tsai M.S., Lee J.L., Chang Y.J., Hwang S.M. Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum. Reprod. 2004; 19: 1450-6.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Bieback K., Kluter H. 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