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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Genes &amp; Cells</journal-id><journal-title-group><journal-title xml:lang="en">Genes &amp; Cells</journal-title><trans-title-group xml:lang="ru"><trans-title>Гены и Клетки</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Genes and Cells</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-1829</issn><issn publication-format="electronic">2500-2562</issn><publisher><publisher-name xml:lang="en">Human Stem Cells Institute</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">121393</article-id><article-id pub-id-type="doi">10.23868/gc121393</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Rol' kletok Clara v podderzhanii postoyanstva i reparatsii povrezhdeniy epiteliya legochnykh dykhatel'nykh putey</article-title><trans-title-group xml:lang="ru"><trans-title>Роль клеток Clara в поддержании постоянства и репарации повреждений эпителия легочных дыхательных путей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zaytsev</surname><given-names>Valeriy</given-names></name><name xml:lang="ru"><surname>Зайцев</surname><given-names>Валерий</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution></institution></aff><pub-date date-type="pub" iso-8601-date="2009-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2009</year></pub-date><volume>4</volume><issue>4</issue><issue-title xml:lang="en">NO4 (2009)</issue-title><issue-title xml:lang="ru">№4 (2009)</issue-title><fpage>8</fpage><lpage>9</lpage><history><date date-type="received" iso-8601-date="2023-01-11"><day>11</day><month>01</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2009, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2009, Эко-Вектор</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://genescells.ru/2313-1829/article/view/121393">https://genescells.ru/2313-1829/article/view/121393</self-uri><abstract xml:lang="ru"><p>Исследования стволовых клеток (СК) и прогениторных клеток эпителия дыхательных путей млекопитающих характеризуются определенной спецификой: слишком часто экспериментальные результаты не дают ясного ответа на поставленные вопросы. В этом плане показательна работа коллектива авторов из Duke University, опубликованная в июньском номере Cell Stem Cell [1]. Исследование посвящено степени участия в постнатальном росте, поддержании гомеостаза и репарации повреждений эпителия легких мыши нереснитчатых бронхиолярных клеток, называемых клетками Клара. Известно, что после окончания постнатального роста ткань эпителия легких переходит в стационарное состояние с очень низкой скоростью обновления клеток. Повреждение же эпителия стимулирует его быстрое восстановление и обновление. Попытки выявить резидентные соматические СК или прогениторные клетки эпителия легких до сих пор приводили к получению неоднозначных результатов.</p></abstract></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Rawlins E.L., Okubo T., Xue Y., Brass D.M., Auten R.L., Hasegawa H., Wang F., Hogan B.L.M. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell 2009; 4(6): 525-34. [Abstract &lt;http://www.cell.com/cell-stem-cell/abstract/S1934-5909(09)00156-8&gt;]</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Evans M.J., Cabral L.J., Stephens R.J., Freeman G. Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2. Exp. Mol. Pathol. 1975; 22: 142-150. [Abstract &lt;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6WFB-4C52FVT-4T&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=bca0b5eb231931f483457fd967776498&gt;]</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Reynolds S.D., Hong K.U., Giangreco A. et al. Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000; 278(6): L1256-L1263. [Full Text &lt;http://ajplung.physiology.org/cgi/content/full/278/6/L1256&gt;]</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Have-Opbroek A.A.W., Randell S.H., Stripp B.R. Stem cells in lung morphogenesis, regeneration, and carcinogenesis. Stem Cell Handbook. Sell S. (Ed.). Humana Press, 2004. P.455-472. [Book &lt;http://www.amazon.com/Stem-Cells-Handbook-Stewart-Sell/dp/1588291138&gt;]</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Emura M. Stem cells of the respiratory tract. Paediatric Resp. Rev. 2002; 3(1): 36-40. [Abstract &lt;http://www.journals.elsevierhealth.com/periodicals/yprrv/article/PIIS1526054202901806/abstract&gt;]</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Hong K.U., Reynolds S.D., Giangreco A., Hurley C.M., Stripp B.R. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am. J. Respir. Cell Mol. Biol. 2001; 24(6): 671-681. [Full Text &lt;http://ajrcmb.atsjournals.org/cgi/content/full/24/6/671&gt;]</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Giangreco A., Reynolds S.D., Stripp B.R. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am. J. Pathol. 2002; 161(1): 173-182. [Full Text &lt;http://ajp.amjpathol.org/cgi/content/full/161/1/173/&gt;]</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Kim C.F., Jackson E.L., Woolfenden A.E., Lawrence S., Babar I., Vogel S., Crowley D., Bronson R.T., Jacks T. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 2005; 121: 823-35. [Abstract &lt;http://www.cell.com/abstract/S0092-8674(05)00342-9&gt;]</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hong K.U., Reynolds S.D., Watkins S., Fuchs E., Stripp B.R. In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004; 286(4): L643-L649. [Full Text &lt;http://ajplung.physiology.org/cgi/content/full/286/4/L643&gt;]</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Rock J.R., Onaitis M.W., Rawlins E.L. et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc. Natl. Acad. Sci. 2009; doi:10.1073/pnas.0906850106. [Abstract &lt;http://www.pnas.org/content/early/2009/07/21/0906850106.abstract&gt;]</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Evans M.J., Shami S.G., Cabral-Anderson L.J., Dekker N.P. Role of nonciliated cells in renewal of the bronchial epithelium of rats exposed to NO2. Am. J. Pathol. 1986; 123(1): 126-133. [Abstract &lt;http://ajp.amjpathol.org/cgi/content/abstract/123/1/126&gt;]</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Akagi K., Sandig V., Vooijs M. et al. Cre-mediated somatic site-specific recombination in mice. Nucl. Acids Res. 1997; 25(9): 1766-73. [Full Text &lt;http://nar.oxfordjournals.org/cgi/content/full/25/9/1766&gt;]</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Hayashi S., McMahon A.P. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol. 2002; 244(2): 305-18. [Abstract &lt;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6WDG-45K16GM-3D&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=b6e1508d1bfe5e93299b371519a212fd&gt;]</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Coraux C., Nawrocki-Raby B., Hinnrasky J. et al. Embryonic stem cells generate airway epithelial tissue. Am. J. Resp. Cell Mol. Biol. 2005; 32(2): 87-92. [Full Text &lt;http://ajrcmb.atsjournals.org/cgi/content/full/32/2/87&gt;]</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Sleuths follow lung stem cells for generations to shed light on healing. ScienceDaily (June 5, 2009). [Full Text &lt;http://www.sciencedaily.com/releases/2009/06/090604144336.htm&gt;]</mixed-citation></ref></ref-list></back></article>
