Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12072910.23868/201808019ArticlesСтатьиResearch ArticleMolecular mechanisms of neuroinflammation initiation and development in a model of post-traumatic stress disorderМолекулярные механизмы инициации и развития нейровоспаления в модели посттравматического стрессового расстройстваTuchinaO. PТучинаО. Пotuchina@kantiana.ruSidorovaM. VСидороваМ. ВTurkinA. VТуркинА. ВShvaikoD. AШвайкоД. АShalaginovaI. GШалагиноваИ. ГVakolyukI. AВаколюкИ. АSchool of Life Sciences, Immanuel Kant Baltic Federal UniversityИнститут Живых Систем Балтийского Федерального Университета им. И. Канта15062018132VOL 13, NO2 (2018)ТОМ 13, №2 (2018)475505012023Copyright ©; 2018, Eco-VectorCopyright ©; 2018, Эко-Вектор2018Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120729

Neuroinflammation causes morphological and functional changes in the nervous tissue and it can be triggered by different kind of stressors. Progress of neuroinflammation as a result of post-traumatic stress disorder (PTSD) is associated with morphological changes in neurons and glial cells, as well as activation of microglia, however the exact molecular mechanisms of these changes are still unknown. In this review we discuss the connections between endocrine, immune and limbic systems during stress, the contributions of each system, the role of blood-brain barrier, as well as current methods and approaches in studying neuroinflammation.

Нейровоспаление как морфофункциональное изменение нервной ткани может возникать под воздействием различного рода стрессовых факторов. Развитие нейровоспаления на фоне посттравматического стрессового расстройства (ПТСР) связано с изменением морфологии нейронов и клеток глии, а также активацией микроглиальных клеток, однако конкретные молекулярные механизмы этих изменений до сих пор неизвестны. В данном обзоре рассматриваются связи между эндокринной, иммунной и лимбической системами при стрессе, их вклад в формирование ПТСР, роль гематоэнцефалического барьера, а также современные методические подходы к исследованию нейровоспаления.

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