Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12072510.23868/201808018ArticlesСтатьиResearch ArticleThe effect of oxygen concentration on embryo development and assisted reproductive technologies efficiencyВлияние концентрации кислорода на развитие эмбрионов и эффективность вспомогательных репродуктивных технологийZhiryaevaE. AЖиряеваЕ. АKiassovA. PКиясовА. ПRizvanovA. AРизвановА. АAlbert.Rizvanov@kpfu.ru“Klinika semejnoj mediciny LLCООО «Клиника семейной медицины»Kazan (Volga region) Federal UniversityКазанский (Приволжский) федеральный университет15062018132VOL 13, NO2 (2018)ТОМ 13, №2 (2018)394605012023Copyright ©; 2018, Eco-VectorCopyright ©; 2018, Эко-Вектор2018Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120725

Many different factors have an effect on the preimplantation development of embryos under conditions in vitro. One of these factors is the oxygen concentration in the culture medium. Currently, IVF labs have ability to cultivate embryos either under conditions of atmospheric oxygen concentration or at low oxygen concentration (hypoxia). This review is focused on the analysis of up to date research and clinical results which are trying to establish an "optimal” composition of the gas mixture in the incubator to generate more viable embryos and increase the effectiveness of assisted reproductive technologies programs.

На преимплантационное развитие эмбрионов в условиях in vitro оказывают влияние множество различных факторов. Одним из таких факторов является концентрация кислорода в среде культивирования. В настоящее время лаборатории ЭКО имеют возможность культивировать эмбрионы как в условиях атмосферного содержания кислорода, так и при пониженных концентрациях кислорода (гипоксии). Настоящий обзор посвящен анализу проведенных исследований по выявлению «оптимальной» концентрации газовой смеси в инкубаторе с целью получения более жизнеспособных эмбрионов и увеличению результативности программ вспомогательных репродуктивных технологий.

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