Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12071610.23868/201808016ArticlesСтатьиResearch ArticleTherapeutic strategies for targeting cancer stem cellsРаковые стволовые клетки как терапевтические мишениAlkonN. SАлконН. СIvanovaA. EИвановаА. ЕFrolovaE. IФроловаЕ. ИChumakovS. PЧумаковС. ПM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the RASИнститут биоорганической химии имени акад. М.М. Шемякина и Ю.А. Овчинникова РАНV.A. Engelhardt Insitute of Molecular Biology of the RASИнститут молекулярной биологии имени В.А. Энгельгардта РАН15062018132VOL 13, NO2 (2018)ТОМ 13, №2 (2018)253405012023Copyright ©; 2018, Eco-VectorCopyright ©; 2018, Эко-Вектор2018Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120716

Cancer stem cells (CSCs) are gaining extensive acknowledge as crucial therapeutic targets for treatment of malignant tumors. CSCs are able to maintain their population and to constantly generate newly differentiated tumor cells. Cancer stem cells that escape treatment are often considered the main source of tumor relapse. Resulting clinical significance had led to extensive studies of stem phenotype-contributing signaling pathways that are often abnormally active in cancer stem cells and CSC-specific traits, that could be used as selective therapeutic targets. Many CSC-targeting therapeutic strategies are currently undergoing clinical trials and evaluation, including various stem cell-specific signaling pathway inhibitors, cancer vaccines based on CSC-primed dendritic cells, monoclonal antibodies and chimeric antigen receptors for adoptive cell immunotherapy.

Раковые стволовые клетки (РСК) получают все большее признание как важные терапевтические мишени для лечения злокачественных опухолей. РСК обладают способностью к поддержанию собственной популяции и непрерывному пополнению гетероморфной массы опухоли новыми клетками. Считается, что рецидивы заболеваний могут возникать после терапии из-за сохранения в организме РСК. Поэтому сейчас особенное внимание уделяется исследованию сигнальных путей, активированных в РСК, а также потенциальных терапевтических мишеней, имеющихся в фенотипе РСК. Выявленные маркеры, а также компоненты сигнальных путей, используются в доклинических и клинических исследованиях новых терапевтических подходов, среди которых выделяют поиск блокаторов сигнальных путей РСК, создание вакцин на основе активированных против РСК дендритных клеток, а также конструирование химерных антигенных рецепторов для применения в адоптивной клеточной терапии.

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