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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Genes &amp; Cells</journal-id><journal-title-group><journal-title xml:lang="en">Genes &amp; Cells</journal-title><trans-title-group xml:lang="ru"><trans-title>Гены и Клетки</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Genes and Cells</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-1829</issn><issn publication-format="electronic">2500-2562</issn><publisher><publisher-name xml:lang="en">Human Stem Cells Institute</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">120706</article-id><article-id pub-id-type="doi">10.23868/201808014</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Fusion-phenomenon in normal histogenesis and in pathology: part 1</article-title><trans-title-group xml:lang="ru"><trans-title>Fusion-феномен в нормальном гистогенезе и при патологии: часть 1</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Buev</surname><given-names>D. O</given-names></name><name xml:lang="ru"><surname>Буев</surname><given-names>Д. О</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Emelin</surname><given-names>A. M</given-names></name><name xml:lang="ru"><surname>Емелин</surname><given-names>А. М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Deev</surname><given-names>R. V</given-names></name><name xml:lang="ru"><surname>Деев</surname><given-names>Р. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.P. Pavlov Ryazan State Medical University</institution></aff><aff><institution xml:lang="ru">Рязанский государственный медицинский университет имени И.П Павлова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Human Stem Cells Institute</institution></aff><aff><institution xml:lang="ru">Институт стволовых клеток человека</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Research Institute of General Pathology and Pathophysiology</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт общей патологии и патофизиологии</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2018</year></pub-date><volume>13</volume><issue>2</issue><issue-title xml:lang="en">VOL 13, NO2 (2018)</issue-title><issue-title xml:lang="ru">ТОМ 13, №2 (2018)</issue-title><fpage>13</fpage><lpage>21</lpage><history><date date-type="received" iso-8601-date="2023-01-05"><day>05</day><month>01</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Эко-Вектор</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://genescells.ru/2313-1829/article/view/120706">https://genescells.ru/2313-1829/article/view/120706</self-uri><abstract xml:lang="en"><p>Various processes happening in human organism depend on cell fusion (also called "fusion-phenomenon”). This review focuses on role of this phenomenon in the histogenesis of different tissues and molecular mechanism of the cell fusion. The Part 1 describes fusion-phenomenon in the normal, physiological conditions.</p></abstract><trans-abstract xml:lang="ru"><p>Процесс слияния клеток (fusion-феномен) лежит в основе множества явлений, протекающих в человеческом организме. Настоящий обзор посвящен роли этого явления в гистогенезе различных тканей, а также его молекулярным механизмам. В первой части описывается fusion-феномен в нормальных - физиологических условиях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cell fusion</kwd><kwd>fusion-phenomenon</kwd><kwd>fertilization</kwd><kwd>myogenesis</kwd><kwd>trophoblast</kwd><kwd>macrophages</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>слияние клеток</kwd><kwd>fusion-феномен</kwd><kwd>оплодотворение</kwd><kwd>миогенез</kwd><kwd>трофобласт</kwd><kwd>макрофаги</kwd><kwd>гистогенез</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Batsida-Ruiz D., Van Hoesen K., Cohen M. The dark side of cell fusion. Int. J. Mol. Sci. 2016; 17(5). doi: 10.3390/ijms17050638.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Hindi S.M., Tajrishi M.M., Kumar A. Signaling Mechanisms in Mammalian Myoblast Fusion. Sci. 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