Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12055910.23868/gc120559ArticlesСтатьиReview ArticleAdipose-derived stromal vascular fraction as an alternative source of cells for the regenerative medicineСтромально-васкулярная фракция жировой ткани как альтернативный источник клеточного материала для регенеративной медициныVeremeevÄ. VВеремеевА. Вal.veremeev@gmail.comBolgarinR. NБолгаринР. НPetkovaM. AПетковаМ. АKatzN.КацН.NesterenkoV. GНестеренкоВ. Г“JoinTechCeir LLCООО «ДжоинТекСэлл»N.F. Gamaleya Federal Research Institute of Epidemiology and MicrobiologyФедеральный научно-исследовательский центр эпидемиологии и микробиологии им. Н.Ф. Гамалеи15032016111VOL 11, NO1 (2016)ТОМ 11, №1 (2016)354205012023Copyright ©; 2016, Eco-VectorCopyright ©; 2016, Эко-Вектор2016Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120559

The adipose tissue is considered as the most convenient and abundant source of cells for the regenerative medicine. The number of progenitor cells in the adipose tissue significantly exceeds their amount in the bone marrow and other tissues. Therefore, adipose-derived stromal vascular fraction comprising distinct populations of stem and progenitor cells can be relatively easily isolated from lipoaspirates and may then be used in various pathological conditions. However, the profile of this cell fraction with a significant therapeutic potential remains unclear, and there are no standardized protocols for its isolation and evaluation. in this article, we reviewed the data on the potential use of adipose-derived stromal vascular fraction in the regenerative medicine. We described the main historical milestones and performed a comprehensive analysis of the sources of adipose-derived stromal vascular fraction, techniques of its isolation, features, immunophenotype and differentiation pathways

Жировая ткань является наиболее удобным и богатым источником клеточного материала для регенеративной медицины вследствие высокого содержания прогениторных клеток, число которых многократно превосходит их количество в костном мозге и других тканях Стромально-васкулярная фракция жировой ткани, содержащая различные популяции стволовых клеток-предшественниц, может быть легко выделена ферментативным способом и использована при различных патологических состояниях. Тем не менее, характеристика клеточного состава с выраженным терапевтическим потенциалом остается неясной, практически отсутствуют стандартизированные протоколы выделения и оценки клеточной фракции В настоящем обзоре проведен анализ литературных данных об использовании стромально-васкулярной фракции жировой ткани для стимулирования процессов регенерации Представлены основные вехи применения стромально-васкулярной фракции жировой ткани в историческом аспекте, источники и способы ее выделения, характеристика состава, иммунофенотип и направления дифференцировки клеток, входящих в её состав.

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