Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12055010.23868/gc120550ArticlesСтатьиReview ArticleMacrophages: diversity of phenotypes and functions, interaction with foreign materialsМакрофаги: разнообразие фенотипов и функций, взаимодействие с чужеродными материаламиSarbaevaN. NСарбаеваН. НPonomarevaJ. VПономареваЮ. Вjvponomareva@mail.ruMilyakovaM. NМиляковаМ. НSamara State Medical UniversityСамарский государственный медицинский университет15032016111VOL 11, NO1 (2016)ТОМ 11, №1 (2016)91705012023Copyright ©; 2016, Eco-VectorCopyright ©; 2016, Эко-Вектор2016Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120550

According to “M1/M2” paradigm two distinct subsets of macrophages have been proposed - classically (M1) or alternatively (M2) activated macrophages that express different receptors, cytokines, chemokines, growth factors and effector molecules but recent evidence suggests that in respond to changed environmental stimuli they can demonstrate unique properties which do not allow to attribute them neither to M1 nor to M2 population. Macrophages play a pivotal role in foreign body reaction following installation of catheters, stents prosthesis, dental implants Macrophages englobe wear particles around joint prosthesis initiating an inflammation in periprosthetic tissues аnd osteolysis, control fibroproliferation and formation of the fibrous capsule surrounding foreign bodies A brief overview of events leading to migration, adhesion and activation of macrophages, and analysis of their functional characteristics on different surfaces including biodegradable and non-biodegradable materials in vivo and in vitro are presented

В соответствии с «М1/М2» парадигмой выделяют два подтипа активированных макрофагов - классически активированные (М1) и альтернативно активированные (М2), которые экспрессируют различные рецепторы, цитокины, хемокины, факторы роста и эффекторные молекулы Однако данные последних лет указывают на то, что в ответ на изменение сигналов микроокружения, макрофаги могут проявлять уникальные свойства, не позволяющие отнести их ни к одному из этих подтипов. Макрофаги играют главную роль в реакции организма на имплантируемый материал - катетеры, стенты, эндопротезы, дентальные имплантаты Макрофаги фагоцитируют частицы износа поверхности суставных протезов, инициируют воспаление в зоне протезирования и остеолиз, управляют процессами образования фиброзной капсулы вокруг инородных тел Представлен краткий обзор факторов, вызывающих миграцию, адгезию и активацию макрофагов, анализ их функциональных характеристик на различных поверхностях, включая биодеградирующие и не деградирующие материалы in vivo и in vitro

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