Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12053610.23868/gc120536ArticlesСтатьиResearch ArticleExperimental models for studying of skeletal muscles regenerationЭкспериментальные модели для изучения регенерации поперечнополосатой скелетной мышечной тканиChernovaO. NЧерноваО. Нolgachernova92@yandex.ruKorsakovI. NКорсаковИ. НSamchukD. PСамчукД. ПPulinA. AПулинА. АMavlikeevM. OМавликеевМ. ОDeevR. VДеевР. ВEreminI. IЕреминИ. ИKazan (Volga region) Federal UniversityКазанский (Приволжский) федеральный университетCentral Clinical Hospital with Outpatient Health Center of the Business Administration for the President of the Russian FederationЦентральная клиническая больница с поликлиникойHuman Stem Cells InstituteИнститут стволовых клеток человека15122015104VOL 10, NO4 (2015)ТОМ 10, №4 (2015)12714005012023Copyright ©; 2015, Eco-VectorCopyright ©; 2015, Эко-Вектор2015Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120536

Striated muscles play an important role in the maintenance in the maintenance of locomotion, ventilation, mechanical protection, the inner organs support, a common system of energy exchange etc. Skeletal muscle tissue is exposed to various external factors which cause notable damage to skeletal tissue as a result of mechanical injury (contusion, compression, laceration), inflammation as an implication of infectious agents and autoimmune process, toxic effects of various chemical substances. Besides the external causes, genes' defects that code muscle protein components have influence on the muscles too. These defects lead to muscular dystrophies (Duchenne Becker muscular dystrophy, dysferlinopathy, calpainopathy etc.). In condition of serious injuries the cambial reserve by means of myosatellite cells and other myogenic cells usually does not provides hysto-and organotypic skeletal muscles regeneration. This fact determines development of new methods for induction of regeneration striated muscles and, in turn, requires amplification of using experimental models of muscles injury for studying regeneration of skeletal muscles The aim of this review is comparative description of experimental models applied for studying of skeletal muscles regeneration after its damage

Известно, что поперечнополосатая мышечная ткань участвует в локомоции, в обеспечении внешнего дыхания, механической защиты, поддержании внутренних органов, в общей системе энергообмена и др. Скелетная мускулатура подвержена воздействию многих факторов, влияние которых часто приводит к повреждению мышц в результате механической травмы (ушиб, компрессия, разрыв), воспаления вследствие воздействия инфекционных агентов и аутоиммунных процессов, токсического воздействия различных химических веществ. Помимо экзогенных факторов на мышечную ткань оказывают влияние и дефекты в генах, кодирующих белки - компоненты мышечного волокна, приводящие к мышечным дистрофиям (мышечная дистрофия Дюшенна/Беккера, дисферлинопатии, кальпаинопатии и т д ) При серьезных повреждениях камбиальный резерв в виде миосателлитоцитов и иных миогенных клеток, как правило, не обеспечивает гисто- и органотипической регенерации скелетных мышц, что обуславливает актуальность разработки новых методов индукции регенерации поперечнополосатой мышечной ткани и, в свою очередь, применение экспериментальных моделей повреждения мышечной ткани для изучения ее регенерации Цель данного обзора - сравнительное описание экспериментальных моделей, используемых для изучения регенерации поврежденной скелетной мышечной ткани

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