Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12046810.23868/gc120468ArticlesСтатьиReview ArticleTargeted radionuclide therapy: current status and prospectsНаправленная радионуклидная терапия: современное состояние и перспективыVodeneevV. AВоденеевВ. АZvyaginA. VЗвягинА. ВShilyaginaN. YuШилягинаН. ЮKulikovD. AКуликовД. АKulikovA. VКуликовА. ВGudkovS. VГудковС. ВN.I. Lobachevsky Nizhny Novgorod State UniversityНижегородский государственный университет им. Н.И. ЛобачевскогоInstitute of Theoretical and Experimental Biophysics Russian Academy of SciencesИнститут теоретической и экспериментальной биофизики РАНM.F. Vladimirsky Moscow Regional Research and Clinical InstituteМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоA.M. Prokhorov Institute of General Physics Russian Academy of SciencesИнститут общей физики им. А.М. Прохорова РАН15062015102VOL 10, NO2 (2015)ТОМ 10, №2 (2015)232905012023Copyright ©; 2015, Eco-VectorCopyright ©; 2015, Эко-Вектор2015Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120468

One of the intensively developing approaches to the treatment of oncologic diseases is directed (targeted) radionuclide therapy. Radionuclide therapy avoids the side effects associated with external beam therapy. Furthermore, it is possible to combine the processes instrumental diagnostics and radiotherapy (theranostics), which leads to personalize the treatment regimen for each individual patient. in this review, we discuss the fundamentals of targeted radionuclide therapy, including the characteristics of the radionuclides and biomolecular targeting moieties information on the targeted radionuclide therapy drugs for approved for clinical use is provided. Prospects and limitations of the targeted radionuclide therapy and their implementation in clinical practice are discussed

Одним из интенсивно развивающихся подходов к лечению злокачественных опухолей является направленная радионуклидная терапия. Ее применение позволяет избежать побочных эффектов и токсичности, связанных с чрезмерным облучением при внешней лучевой терапии. Кроме того, с применением этого способа появляется возможность объединить процессы инструментальной диагностики и радиотерапии (тераностика), что ведет к персонализации схемы лечения каждого конкретного пациента В обзоре рассмотрены основные принципы направленной радионуклидной терапии, включая характеристику используемых радиоактивных изотопов и молекул, которые их переносят Приведены сведения о препаратах, одобренных для клинического применения и находящихся в процессе клинических исследований. Проанализированы трудности, препятствующие широкому внедрению в медицинскую практику направленной радионуклидной терапии, пути их преодоления и перспективы развития данной технологии

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