Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12046310.23868/gc120463ArticlesСтатьиReview ArticleTechnologies of cellular antitumor immune response induction in vitroТехнологии индукции клеточного противоопухолевого иммунного ответа in vitroSennikovS. VСенниковС. Вsennikov_sv@mail.ruKulikovaE. VКуликоваЕ. ВObleukhovaI. AОблеуховаИ. АShevchenkoJ. AШевченкоЮ. АResearch Institute of Fundamental and Clinical ImmunologyНаучно-исследовательский институт фундаментальной и клинической иммунологии15062015102VOL 10, NO2 (2015)ТОМ 10, №2 (2015)162205012023Copyright ©; 2015, Eco-VectorCopyright ©; 2015, Эко-Вектор2015Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120463

Dendritic cells are “professional” antigen-presenting cells and the most potent stimulators of various immune responses of the organism, including antitumor. Modern studies have shown that an effective antitumor immune response doesn't occur in patients with malignant tumors. This is largely due to a decrease in functional activity of dendritic cells in cancer patients through irregularities in the maturation process to a functionally active form and in the antigen presentation process to naive T lymphocytes This review describes the main stages in technology of cellular antitumor immune response induction in vitro, aimed at resolution of the problems blocking the full functioning of dendritic cells, and additional stimulation of antitumor immune response, as well as prospects for the technology development

Дендритные клетки являются «профессиональными» антиген-презентирующими клетками и наиболее мощными стимуляторами различных иммунных ответов организма, в том числе противоопухолевого. Современными исследованиями показано, что при злокачественных новообразованиях у пациентов не происходит формирования эффективного противоопухолевого иммунного ответа. Во многом, это связано со снижением функциональной активности дендритных клеток у онкологических больных за счет нарушений в процессе созревания до функционально-активных форм и в процессе презентации антигена наивным Т-лимфоцитам. В обзоре освещены основные этапы технологии индукции клеточного противоопухолевого иммунного ответа in vitro, направленные на решение проблем, препятствующих полноценному функционированию дендритных клеток, и на дополнительную стимуляцию противоопухолевого иммунного ответа, а также перспективы развития технологии

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