Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12045910.23868/gc120459ArticlesСтатьиReview ArticleThe role of EF-hand Са2+/Mg2+-binding tescalcin protein in cell proliferation and differentiationРоль EF-hand Ca2+/Mg2+-связывающего белка тескалцина в процессах пролиферации и дифференцировки клетокKolobyninaK. GКолобынинаК. ГSolovyevaV. VСоловьеваВ. ВSlepakV. ZСлепакВ. ЗRizvanovA. AРизвановА. АAlbert.Rizvanov@kpfu.ruKazan (Volga Region) Federal UniversityКазанский (Приволжский) федеральный университетUniversity of Miami Miller School of MedicineМедицинская школа Миллера при Университете Майами15032015101VOL 10, NO1 (2015)ТОМ 10, №1 (2015)283405012023Copyright ©; 2015, Eco-VectorCopyright ©; 2015, Эко-Вектор2015Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120459

EF-hand Са2+/Мд2+-binding proteins are involved in many important processes in the body. Identification and analysis of the EF-hand motifs in the genome led to the discovery of novel Ca2+-binding proteins, which are potentially useful for biomedical applications. One of such molecules is tescalcin - 24 kDa protein with one EF-hand motif. Tescalcin plays an important role in differentiation of hematopoietic cells by regulating the expression of Ets family transcription factors via PMA-induced ERK-pathway. At the molecular level, it was shown to interact with subunit 4 of signalosome COP9 and Na+/H+-exchanger. Recently a potential use of tescalcin for cancer diagnostics was demonstrated

EF-hand Са2+-связывающие белки принимают участие во многих важных процессах в организме, включая передачу сигналов, регуляцию ионных токов и дифференцировку. Идентификация и анализ EF-hand мотивов в геноме привели к открытию новых Са2+-связывающих белков, которые потенциально применимы для биомедицинских показаний Одним из таких молекул является тескалцин, белок с молекулярной массой 24 кДа, имеющий один EF-hand мотив. Тескалцин играет важную роль в дифференцировке гемопоэтических клеток, а также взаимодействует с субъединицей 4 сигналосомы COP9, №+/Н+-антипортом 1 типа и контролирует экспрессию факторов транскрипции семейства Ets через PMA-индуцированный ERK-путь. Недавно были описаны потенциальные возможности применения тескалцина для диагностики онкологических заболеваний

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