In the last decade barrier the application of different types of membranes in the oral and maxillofacial surgery has been increasing. Their main reliability features include resorption times, the lack of toxic and antigenic effects, the absence of negative effects from the membrane on the structure of the surrounding soft tissues, as well as a high degree of biointegration and a potentiality of steady stabilization in the wound. Considering the abovementioned parameters, graft barrier membranes are a material of choice in the modern reconstructive oral and maxillofacial surgery. The present study includes an experimental and morphological assessment of biologic xenogenic barrier membranes for the evaluation of their immunological potency and the time of biodegradation using a model test system in vivo. Three groups of barrier membranes were assayed - M-D (decellu-larized diaphragm), M-P (pericardium), M-DM (dura mater), prepared from the corresponding tissues of a mature ox, in accordance to the method developed in the Priorov Central Research Institute of Traumatology and Orthopaedics. The experiments were carried out on a model of 6-week heterotopic subcutaneous implantation in rats and included a complex histological and immunohistochemical analysis, with quantitative estimation of biograft mineralization by adsorption spectroscopy. It was found that: the material of M-DM has the highest and fullest (while retaining the strength properties) resorption; a relatively long bi-odegradation time, expressed conductive effect and constraint function are specific for the М-Р material; M-D membranes have faster resorption, enhanced thinning and relative biological inertness. The results of the conducted study indicate that all the implanted materials are biocompatible and efficient, and thus may be used in various medical cases.