Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12035610.23868/gc120356ArticlesСтатьиMiscellaneousPharmacogenetic and bioengineering approaches to the treatment of glial tumors of the brainФАРМАКОГЕНЕТИЧЕСКИЙ И БИОИНЖЕНЕРНЫЙ ПОДХОДЫ К ЛЕЧЕНИЮ ГЛИАЛЬНЫХ ОПУХОЛЕЙ ГОЛОВНОГО МОЗГАBryukhovetskiyI. SБрюховецкийИ. СBryukhovetskiyAБ. SБрюховецкийА. СKhotimchenkoY. SХотимченкоЮ. СFar Eastern Federal UniversityДальневосточный федеральный университет1509201493VOL 9, NO3 (2014)ТОМ 9, №3 (2014)14014605012023Copyright ©; 2014, Eco-VectorCopyright ©; 2014, Эко-Вектор2014Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/120356

The article analyzes the existing ideas about the specific mechanisms of therapeutic resistance of glial tumors of the brain, systematized the main trends in modern chemotherapy glial tumors, an attempt to justify the new bioengineering approaches to the creation of personalized cell preparations for therapy of glial tumors based on molecular - biological characteristics of tumor stem cells. It is shown that the main tool of the therapeutic effects can be own stem cells of cancer patients and tumor stem cell proteome can be considered as the primary target cell therapy.

В обзоре проведен анализ существующих представлений о специфике механизмов терапевтической резистентности глиальных опухолей головного мозга, систематизированы основные тенденции в современной химиотерапии глиальных опухолей, предпринята попытка обоснования новых, биоинженерных подходов к созданию персонифицированных клеточных препаратов для терапии глиальных опухолей с учетом молекулярно-биологических характеристик опухолевых стволовых клеток. Показано, что основным инструментом терапевтического воздействия могут быть собственные стволовые клетки онкологического больного, а протеом опухолевой стволовой клетки может рассматриваться как основная мишень клеточной терапии.

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