The tendention in creative tissue engineering of osteoplastice

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Abstract

In this papier there are basic requirements for materials which are intended for compensation of defects of bones by means of their implantation, and also there are approaches for choosing the sources and technical receptions in industrial manufacture. The dates about approbation in experiment of osteoplastic materials of INDOST, which are developed in compliance with this criterions are shown.

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About the authors

K. S. Desyatnichenko

JSC «NPO “POLYSTOM"»

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow

S. G. Kurdyumov

JSC «NPO “POLYSTOM"»

Email: info@eco-vector.com
Russian Federation, Moscow

References

Supplementary files

Supplementary Files
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2. Figure 1. The mechanism of osteoreparation during implantation of a two-component tissue engineering system

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3. Figure 2. The mechanism of osteoreparation during implantation of a tissue engineering system with the inclusion of growth-regulating factors: KFR - bone growth-regulating factors

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4. Figure 3. Approximate composition of mature compact bone tissue: GAG - gliazaminoglycans; NBK - non-collagen bone proteins

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5. Figure 4. "Decision tree" when choosing the source of the CRF

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6. Figure 5. Scheme for isolating the composition of CRF from xenogenic bone tissue

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7. Figure 6. Granulation tissue in diastasis between tibial fragments after 7 days. after implantation of INDOST into a diaphyseal defect. Stained with hematoxylin and eosin. x100

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8. Figure 7. 7 days after implantation of INDOST into a perforated defect of the lower jaw. Osteoclasts (arrows) at the interface between the implant and the bone bed. Stained with hematoxylin and eosin. x200

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9. Figure 8. 15 days after compensation of the perforated defect by INDOST. Staining: A - hematoxylin and eosin; B - picrofuchsin. x200

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10. Figure 9. Cartilaginous tissue in diastasis between fragments of the tibia on the 15th day. after compensation of the diaphyseal defect with COLAPOL. Staining: Schiff's reagent. x100

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11. Figure 10. Bone tissue after 75 days. after implantation of INDOST into a perforated defect. Staining: A - with hematoxylin and eosin. x100; B - picrofuchsin. x200

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12. Figure 11. Compensation for a perforated defect of the femur, control, 75 days: A - actively rebuilding the newly formed bone. Stained with hematoxylin and eosin. x200; B - collagen isoforms of different maturity. Stained with picrosirius. x100

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13. Figure 12. 30 days after compensation of the perforated defect with INDOST containing HA and TCP in the form of ~100 µm particles. Stained with hematoxylin and eosin. x100

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