Prevention of acute and chronic allograft rejection with CD4+CD25+FохрЗ+ regulatory Т-lymphocytes
- Authors: Sergeev V.S.
- Issue: Vol 3, No 4 (2008)
- Pages: 10-12
- Section: Cell technology
- URL: https://genescells.ru/2313-1829/article/view/192530
- ID: 192530
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References
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Mechanisms of direct and indirect recognition of alloantigens. The direct mechanism is based on the migration of the donor APC from the transplant to the regional lymph nodes of the recipient, where the MHC II-peptide complexes expressed on their surface are recognized by T-lymphocytes. With indirect recognition, recipient APCs absorb antigens of the minor histocompatibility complex, the source of which is the transplant cells. Then APC again migrate to the regional lymph nodes and present antigens with their own MHC II molecules.
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