Biosafety Preclinical Trials of Xenogenic, Allogeniec and Autologous Progenitor Cells from Fat Tissue
- Authors: Melikhova V.S.1, Saburina I.N.1, Orlov A.A.2, Repin V.D.1, Novikova N.I.3, Murashev A.N.3
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Affiliations:
- Institute of General Pathology and Pathophysiology
- Clinical Hospital №85, Moscow
- Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS
- Issue: Vol 3, No 3 (2008)
- Pages: 43-46
- Section: Original Study Articles
- URL: https://genescells.ru/2313-1829/article/view/163946
- ID: 163946
Cite item
Abstract
Due to wide spread of new methods of regenerative medicine on basis of stem cells it has become increasingly necessary to establish standards of techniques using them. Preclinical trial of a new technology after receiving preliminary experiment results is a primary stage of its adoption. We carried out the experiments to assess biosafety of autogenous, allergenic and xenogeneic cultures of human and rat cells in models under standard preclinical experiments conditions used in a presentday pharmacological practice.
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About the authors
V. S. Melikhova
Institute of General Pathology and Pathophysiology
Author for correspondence.
Email: bozo.ilya@gmail.com
Russian Federation, Moscow
I. N. Saburina
Institute of General Pathology and Pathophysiology
Email: bozo.ilya@gmail.com
Russian Federation, Moscow
A. A. Orlov
Clinical Hospital №85, Moscow
Email: bozo.ilya@gmail.com
Russian Federation, Moscow
V. D. Repin
Institute of General Pathology and Pathophysiology
Email: bozo.ilya@gmail.com
Russian Federation, Moscow
N. I. Novikova
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: bozo.ilya@gmail.com
Russian Federation, Puschino
A. N. Murashev
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: bozo.ilya@gmail.com
Russian Federation, Puschino
References
- Хабриев Р.У. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ. 2005; М., Медицина: 832.
- Федеральный Закон «О лекарственных средствах». Принят Государственной Думой 5 июня 1998 г.
- Astori G., Vignati F., Bardelli S. et al. «In vitro» and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells. J. Transl. Med. 2007; 5: 55.
- Zuk P.A., Zhu M., Ashjian P. et al. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell. 2002; 13(12): 4279-95.
- Bernardo M.E., Zaffaroni N., Novara F. et al. Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res. 2007; 67(19): 9142-9.
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