EVALUATION OF BIOCOMPATIBILITY AND EFFICIENCY OF PLASMID DNA DELIVERY BY GENE- ACTIVATED HYDROGELS IN VITRO
- Authors: Bozo I.Y1,2,3, Titova A.A4, Zhuravleva M.N4, Bilyalov A.I4, Mavlikeev M.O4, Yakovlev I.A5, Eremin I.I1,6, Pulin A.A1,7, Komlev V.S8, Deev R.V3,5,9
-
Affiliations:
- Research Institute of General Pathology and Pathophysiology
- A.I. Burnazyana Federal Medical Biophysical Center, FMBA of Russia
- Histograft, LLC
- Kazan (Volga Region] Federal University
- I.P. Pavlov Ryazan State Medical University
- National Research Center “Kurchatov Institute"
- N.I. Pirogov National Medical Surgical Center
- A.A. Baykov Institute of Metallurgy and Materials Science of the RAS
- PJSC “Human Stem Cells Institute"
- Issue: Vol 14, No 2 (2019)
- Pages: 40-46
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/122206
- DOI: https://doi.org/10.23868/201906017
- ID: 122206
Cite item
Abstract
Full Text
About the authors
I. Y Bozo
Research Institute of General Pathology and Pathophysiology; A.I. Burnazyana Federal Medical Biophysical Center, FMBA of Russia; Histograft, LLC
Email: bozo.ilya@gmail.com
A. A Titova
Kazan (Volga Region] Federal University
M. N Zhuravleva
Kazan (Volga Region] Federal University
A. I Bilyalov
Kazan (Volga Region] Federal University
M. O Mavlikeev
Kazan (Volga Region] Federal University
I. A Yakovlev
I.P. Pavlov Ryazan State Medical University
I. I Eremin
Research Institute of General Pathology and Pathophysiology; National Research Center “Kurchatov Institute"
A. A Pulin
Research Institute of General Pathology and Pathophysiology; N.I. Pirogov National Medical Surgical Center
V. S Komlev
A.A. Baykov Institute of Metallurgy and Materials Science of the RAS
R. V Deev
Histograft, LLC; I.P. Pavlov Ryazan State Medical University; PJSC “Human Stem Cells Institute"
References
- Lev R., Seliktar D. Hydrogel biomaterials and their therapeutic potential for muscle injuries and muscular dystrophies. J.R. Soc. Interface. 2018; 15(138): pii: 20170380.
- Ruvinov E., Tavor Re'em T., Witte F., Cohen S. Articular cartilage regeneration using acellular bioactive affinity-binding alginate hydrogel: A 6-month study in a mini-pig model of osteochondral defects. J. Orthop. Translat. 2018; 16: 40-52.
- Li L., Yu F., Zheng L. et al. Natural hydrogels for cartilage regeneration: Modification, preparation and application. J. Orthop. Translat. 2018; 17: 26-41.
- Mandla S., Davenport Huyer L., Radisic M. Review: Multimodal bioactive material approaches for wound healing. APL Bioeng. 2018; 2(2): 021503.
- Деев р.В., Дробышев А.Ю., Бозо И.Я. ординарные и активированные остеопластические материалы. Вестник травматологии и ортопедии им. Н.Н. Приорова 2015; 1: 51-69.
- Komatsu K., Shibata T., Shimada A., et al. Cationized gelatin hydrogels mixed with plasmid DNA induce stronger and more sustained gene expression than atelocollagen at calvarial bone defects in vivo. J. Biomater. Sci. Polym. Ed. 2016; 27(5): 419-30.
- Mulder G., Tallis A.J., Marshall V.T., et al. Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GAM501): results of a phase 1/2 trial. Wound Repair Regen. 2009; 17(6): 772-9.
- Blume P., Driver V.R., Tallis A.J., et al. Formulated collagen gel accelerates healing rate immediately after application in patients with diabetic neuropathic foot ulcers. Wound Repair Regen. 2011; 19(3): 302-8.
- Shapiro G., Lieber R., Gazit D. et al. Recent Advances and Future of Gene Therapy for Bone Regeneration. Curr. Osteoporos. Rep. 2018; 16(4): 504-11.
- Bozo I.Y., Deev R.V., Drobyshev A.Y. et al. World's First Clinical Case of Gene-Activated Bone Substitute Application. Case Rep. Dent. 2016; 2016: 8648949.
- Деев р.В., Дробышев А.Ю., Бозо И.Я. и др. создание и оценка биологического действия ген-активированного остеопластического материала, несущего ген VEGF человека. Клеточная трансплантология и тканевая инженерия 2013; 8(3): 78-85.
- Червяков Ю.В., староверов И.Н., Власенко о.Н. и др. Пятилетние результаты лечения больных хронической ишемией нижних конечностей с использованием генной терапии. Ангиология и сосудистая хирургия 2016; 22(4): 38-45.
- Villate-Beitia I., Truong N.F., Gallego I. et al. Hyaluronic acid hydrogel scaffolds loaded with cationic niosomes for efficient non-viral gene delivery. RSC Adv. 2018; 8(56): 31934-42.
- Tokatlian T., Cam C., Segura T. Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice. Biomaterials 2014; 35(2): 825-35.