Gene-activated hydrogels in regenerative medicine



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Abstract

Hydrogels capable to optimize reparative regeneration and delivere biologically active components (drugs, cells, growth factors, gene constructs) in the implantation area are attracting increasing attention of developers due to high potential effectiveness of these medical devices and compliance of the approach with well-known medical trend - minimally invasive technologies. Hydrogels containing gene constructs have become especially relevant for clinical practice in the territory of the Eurasian Customs Union after gen-therapeutic drug and the first gene-activated bone substitute were registered in Russia. This review describes the main directions in development of gene-activated hydrogels divided into two categories: primitive and optimized ("smart”-hydrogels). In the case hydrogel scaffolds provide passive delivery of gene constructs, while the latter facilitate gene constructs to realize their mechanism of action.

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About the authors

I. Y Bozo

Research Institute of General Pathology and Pathophysiology; A.I. Burnazyana Federal Medical Biophysical Center, FMBA of Russia; Histograft, LLC

Email: bozo.ilya@gmail.com

A. I Bilyalov

Kazan (Volga Region] Federal University

M. O Mavlikeev

Research Institute of General Pathology and Pathophysiology

R. V Deev

I.P. Pavlov Ryazan State Medical University; Institute of Human Stem Cells, PJSC

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