Microglia histogenesis: the history of research

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The researches of histogenesis and histophysiology of microglia and its role in evolution of central nervous system pathology attract less attention than it should. The proposed review is devoted to the problem of microglia's origin and history of microglia research. Various number of hypotheses concerning microglia histogenesis were suggested in different periods, specifically the hypothesis about ectodermal or mesodermal (mesenchymal) histogenesis of microglia and its origin. This review represents the role of domestic and international histologists in study of microglia histogenesis, especially the role of professor Beletskiy.

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About the authors

R. V Deev

I.P. Pavlov Ryazan State Medical University; PJSC “Human Stem Cells Institute"

M. V Dikonenko

S.M. Kirov Military Medical Academy

U. P Grechanik

S.M. Kirov Military Medical Academy


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