Epicardium as a new target for regenerative technologies in cardiology

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Epicardium is actively involved in the embryonic heart development and its repair after injury, which allows it to be considered as a potential target for the treatment of heart diseases. In this regard, the study of the mechanisms of its development, the components of the microenvironment, as well as the signals regulating the behavior of epicardial progenitor cells, is the most important area of modern cardiology. This review considers the results of recent studies of homeostasis of epicardial cells and technological advances to modulate their activity, which is essential for the development of new therapeutic agents.

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About the authors

K. V Dergilev

Institute of Experimental Cardiology National Medical Research Center for Cardiology

Email: doctorkote@gmail.com
Moscow, Russia

A. V Komova

Institute of Experimental Cardiology National Medical Research Center for Cardiology

Email: doctorkote@gmail.com
Moscow, Russia

Z. I Tsokolaeva

Institute of Experimental Cardiology National Medical Research Center for Cardiology; V.A. Negovsky Research Institute of General Reanimatology Federal Scientific and Clinical Center of Reanimatology and Rehabilitation

Email: doctorkote@gmail.com
Moscow, Russia; Moscow, Russia

I. B Beloglazova

Institute of Experimental Cardiology National Medical Research Center for Cardiology

Email: doctorkote@gmail.com
Moscow, Russia

Ye. V Parfyonova

Institute of Experimental Cardiology National Medical Research Center for Cardiology; M.V. Lomonosov Moscow State University

Email: doctorkote@gmail.com
Moscow, Russia; Moscow, Russia


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