Elastic ear cartilage of Acomys mice is recovering after injury

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The article presents data on the regeneration of the auricle tissues of Acomys cahirinus mice (n=12) and Balb/c mice (n=12). Two experimental models were used: a full-thickness perforated defect with a diameter of 3 mm and subtotal removal of the auricle. Macrophotography and histological examination using general histological stains and detection of elastic fibers were performed after 2, 5, 15, 21, 30, 60, 90, and 120 days. It was found that regeneration in Acomys is more pronounced, which manifested itself in the complete elimination of the defect by 30-60 days in contrast to the control (Balb/c). A feature of this was less pronounced post-traumatic inflammation in Acomys mice. It was established the growth of a full-fledged auricle in case of its surgical removal. An important feature of regeneration in this case is the development of new cartilage tissue both from the edges of the original cartilage and developed in the form of separate islands of cartilage tissue. The newly formed cartilage was characterized by high cel-lularity, a smaller volume of the matrix, in the structure of which elastic fibers were formed. However, it should be noted that within 30-60 days. the recovery process, apparently, is not completed, the formed tissue regenerate enters the remodeling phase.

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About the authors

A. I Bilyalov

Kazan (Volga region) federal university; The Loginov Moscow Clinical Scientific Center Under the Health Department of Moscow

D. D Filimoshina

Kazan (Volga region) federal university

N. S Filatov

Kazan (Volga region) federal university

A. A Bilyalova

Kazan (Volga region) federal university

A. A Titova

Kazan (Volga region) federal university

L. R Gataullina

Kazan (Volga region) federal university

A. S Plushkina

Kazan (Volga region) federal university

E. I Shagimardanova

Kazan (Volga region) federal university

R. V Deev

I.I. Mechnikov North-Western State Medical University

A. P Kiyasov

Kazan (Volga region) federal university

O. S Kozlova

Kazan (Volga region) federal university

A. A Nesmelov

Kazan (Volga region) federal university

O. A Gusev

Kazan (Volga region) federal university; Juntendo University; Endocrinology Research Centre


  1. Tuan R.S., Chen A.F., Klatt B.A. Cartilage regeneration. J.Am. Acad. Orthop. Surg. 2013; 21(5): 303-11.
  2. Trengove A., Di Bella C., O'Connor A. The Challenge of Cartilage Integration: Understanding a Major Barrier to Chondral Repair. Tissue Engineer. Part B: Rev. 2022; 28(1): 114-28
  3. Gvaramia D., Kern J., Jakob Y. et al. Regenerative Potential of Perichondrium: A Tissue Engineering Perspective. Tissue Engineer. Part B. Rev. 2022; 28(3): 531-41.
  4. Kobayashi S., Takebe T., Inui M. et al. Reconstruction of human elastic cartilage by a CD44+ CD90+ stem cell in the ear perichondrium. PNAS USA 2011; 108(35): 14479-84.
  5. Iwaniak P., Dobrowolski P., Tomaszewska E. et al. The influence of dexamethasone administered prenatally on cartilage of newborn spiny mouse (Acomys cahirinus) offspring. J. Dev. Orig. Health Dis. 2016; 7(3): 298-305.
  6. Maden M., Varholick J.A. Model systems for regeneration: the spiny mouse, Acomys cahirinus. Dev. (Cambridge, Eng.). 2020; 147(4): dev167718.
  7. Rai M.F., Sandell L.J. Regeneration of articular cartilage in healer and non-healer mice. Matrix Biol. 2014; 39: 50-5.
  8. Seifert A.W., Kiama S.G., Seifert M.G. et al. Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature 2012; 489(7417): 561-5.
  9. Oh S.J., Park H.Y., Choi K.U. et al. Auricular Cartilage Regeneration with Adipose-Derived Stem Cells in Rabbits. Mediators Inflamm. 2018; 2018: 4267158.
  10. Пресняков Е.В., Рочев Е.С., Церцеил В.В. и др. Индукция хондрогенеза in vivo под влиянием гидрогелевого ген-активированного материала на основе гиалуроновой кислоты и плазмидной ДНК с геном VEGF. Гены и Клетки 2021; XVI(2): 47-53.
  11. Grol M.W., Lee B.H. Gene therapy for repair and regeneration of bone and cartilage. Curr Opin Pharmacol. 2018; 40: 59-66.
  12. Wasyteczko M., Sikorska W., Chwojnowski A. Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering. Membranes (Basel). 2020; 10(11): 348.

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