The first clinical experience of direct gene therapy using VEGF and bFGF in treatmentpatients with critical lower limb ischemia
- Authors: Plotnikov MV1,2,3, Rizvanov AA1,4,3, Masgutov RF1,4,5,3, Mavlikeev MO5, Salafutdinov II1,4,3, Gazizov IM5, Romanova YD4, Shamsutdinova II1, Bogov AA1,5,3, Maksimov AV1,2,3
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Affiliations:
- Republican Clinical Hospital, Kazan
- Kazan State Medical Academy, Kazan
- Kazan (Volga Region) Federal University, Kazan
- Kazan State Medical University, Kazan
- Issue: Vol 7, No 3 (2012)
- Pages: 180-184
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121717
- DOI: https://doi.org/10.23868/gc121717
Cite item
Full Text
Abstract
successful treatment of distal form of peripheral artery
disease of the lower extremity with symptoms of critical
ischemia in a 60 years old patient.
Intramuscular injection of dual expression plasmid, encoding
vascular endothelial growth factor VEGF and basic fibroblast
growth factor FGF2, was performed to the affected lower
extremity. The effect of treatment was evaluated by functional
tests: measurement of ankle-brachial index, treadmill test, the
recovery time, shoulder-ankle index after strain and temporary
occlusion. Performed immunohistochemical examination of
biopsy samples of the affected lower extremity muscles.
About the authors
M V Plotnikov
Republican Clinical Hospital, Kazan;Kazan State Medical Academy, Kazan;Republican Clinical Hospital, Kazan;Kazan State Medical Academy, Kazan;
A A Rizvanov
Republican Clinical Hospital, Kazan;Kazan (Volga Region) Federal University, Kazan;Republican Clinical Hospital, Kazan;Kazan (Volga Region) Federal University, Kazan;
R F Masgutov
Republican Clinical Hospital, Kazan;Kazan (Volga Region) Federal University, Kazan;Kazan State Medical University, Kazan;Republican Clinical Hospital, Kazan;Kazan (Volga Region) Federal University, Kazan;Kazan State Medical University, Kazan;
M O Mavlikeev
Kazan State Medical University, KazanKazan State Medical University, Kazan
I I Salafutdinov
Republican Clinical Hospital, Kazan;Kazan (Volga Region) Federal University, Kazan;Republican Clinical Hospital, Kazan;Kazan (Volga Region) Federal University, Kazan;
I M Gazizov
Kazan State Medical University, KazanKazan State Medical University, Kazan
Y D Romanova
Kazan (Volga Region) Federal University, KazanKazan (Volga Region) Federal University, Kazan
I I Shamsutdinova
Republican Clinical Hospital, KazanRepublican Clinical Hospital, Kazan
A A Bogov
Republican Clinical Hospital, Kazan;Kazan State Medical University, Kazan;Republican Clinical Hospital, Kazan;Kazan State Medical University, Kazan;
A V Maksimov
Republican Clinical Hospital, Kazan;Kazan State Medical Academy, Kazan;Republican Clinical Hospital, Kazan;Kazan State Medical Academy, Kazan;
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