Algorithm activity of the Stem Cells Bank-Register in Moscow

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Abstract

Progress in transplantation of allogeneic hematopoietic stem cells (HSC) of umbilical cord blood is associated with development of cord blood banks established to provide for the systematic collection, testing, processing, storage, organization and delivery of samples matching cord blood for transplantation. The aim of the study was to develop the algorithm of the Moscow bank's register of unrelated donor of umbilical cord blood HSC. The article described the biological characteristics of all the samples of umbilical cord blood, entered in the register remunerated donors of HSC of Moscow umbilical cord blood stem cell bank (as of 1cryopreservedcord blood sample). It is shown that a small number of unrelated donor of umbilical cord blood HSC in the register allow to select a compatible (6/6), donor-recipient pair with a frequency of 1:151probability. The proposed algorithm of the Moscow bank-register is recommended to use in creating, upgrading and operation of other bank-registers gratuitous unrelated donor of umbilical cord blood HSC.

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About the authors

I. V Kobzeva

Moscow Stem Cell Bank, Moscow

T. A Astrelina

Moscow Stem Cell Bank, Moscow

M. V Yakovleva

Moscow Stem Cell Bank, Moscow

E. E Karpova

Moscow Stem Cell Bank, Moscow

Y. A Kruglova

Moscow Stem Cell Bank, Moscow

L. L Lebedeva

Moscow Stem Cell Bank, Moscow

T. V Puhlikova

Moscow Stem Cell Bank, Moscow

A. A Chumak

Moscow Stem Cell Bank, Moscow

D. S Stavcev

Moscow Stem Cell Bank, Moscow

A. E Gomzyakov

Moscow Stem Cell Bank, Moscow

E. V Boyakova

Moscow Stem Cell Bank, Moscow

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