Stem cells in carcinogenesis of glioblastoma multiforme

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Glioblastoma multiforme is a malignant primary brain tumor with a very poor prognosis. Neural stem and progenitor cells of the adult brain, as well as other types of stem cells are considered by carcinogenesis researchers the most likely source of malignant gliomas. This is evidenced by common genes regulating key processes of life, uniform proteomic profiles and identical immunophenotypical cell surface markers. These cells are highly proliferative, multipotent, able to independently migrate to the damaged area and have extensive replicative potential. However, antitumor properties of the stem cells (SCs) are also confirmed. The bodies of adult mammals and humans have genetically fixed mechanisms of control over their populations and multiple levels of antitumor protection. So far, the role of autologous SCs in a tumor patient is not clear. On the one hand, they fail to fulfill their anti-tumor and regulatory functions, and instead of organizing anti-tumor response become one of the key elements of carcinogenesis contributing to the development of neoplastic tumor vascular network and modulating the processes of neurogenesis, which is the main source of its pathological reinnervation, and therefore, a pain. On the other hand, autologous stem cells trigger powerful proliferative processes in the tumor tissue becoming the driving force of neoplastic growth. Apparently, due to the interaction of tumor cells with autologous stem cells, general and local interstitial patterns of autoregulation and sanogenesis are disturbed making tumor growth possible in principle. From this perspective, the technology that directly affects the population of cancer stem cells seems the most promising.

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About the authors

IS. S Bryukhovetskyi

A.V. Zhirmunsky Institute of Marine Biology of the FEB RAS, Vladivostok

A. S. Bryukhovetskyia

Federal Research Centre of Specialized Types of Medical Care and Technologies of the FMBA of Russia, Moscow

V. V Kumeiko

Far Eastern Federal University, Vladivostok

P. V Mischenko

Far Eastern Federal University, Vladivostok

Y. S Khotimchenko

Far Eastern Federal University, Vladivostok


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