С-kit-positive progenitor cells activation in rats pancreas after partial hepatectomy
- Authors: Kaligin MS1, Plushkina AS1, Gazizov IM1, Sharipova EI1, Gymerova AA1,2,3, Kiassov AA1,2,3
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Affiliations:
- Kazan State Medical University, Kazan
- Kazan (Volga Region) Federal University, Kazan
- Issue: Vol 7, No 3 (2012)
- Pages: 77-79
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121589
- DOI: https://doi.org/10.23868/gc121589
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Full Text
Abstract
cells is a stem cell factor receptor C-kit. According to some
authors, this marker is presented in islet cells of normal rat
pancreas. But it is unknown about the behavior of these cells in
disorders of carbohydrate metabolism during liver disease. The
aim of our study was to evaluate C-kit expression in pancreas
after partial hepatectomy in rats. Partial hepatectomy was
performed for 27 white male rats. The expression of C-kit,
insulin and glucagon in rats pancreas was studied. The
expression of C-kit in islets and interstitial cells was shown
in results after 3 days of the experiment, and double staining
showed that these cells can express glucagon. Thus, there
is the activation of C-kit+ progenitor cells in pancreas after
partial hepatectomy and the beginning of there differentiation
to -cells of Langerhance islets.
About the authors
M S Kaligin
Kazan State Medical University, KazanKazan State Medical University, Kazan
A S Plushkina
Kazan State Medical University, KazanKazan State Medical University, Kazan
I M Gazizov
Kazan State Medical University, KazanKazan State Medical University, Kazan
E I Sharipova
Kazan State Medical University, KazanKazan State Medical University, Kazan
A A Gymerova
Kazan State Medical University, Kazan;Kazan (Volga Region) Federal University, Kazan;Kazan State Medical University, Kazan;Kazan (Volga Region) Federal University, Kazan;
A A Kiassov
Kazan State Medical University, Kazan;Kazan (Volga Region) Federal University, Kazan;Kazan State Medical University, Kazan;Kazan (Volga Region) Federal University, Kazan;
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