Changes of the inflammatory activity and fibrosis in patients with alcoholic liver cirrhosis after autologoushematopoietic stem cell transplantation
- Authors: Burganova GR1, Abdulkhakov SR1, Gumerova AA1, Gazizov IM1, Yylmaz TS1, Titova MA1, Odintsova AK.1, Kiyasov AP1, Burganova GR2, Abdulkhakov SR2, Gumerova AA2, Gazizov IM2, Yilmaz TS2, Titova MA2, Odintcova AK.3, Kiassov AP2
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Affiliations:
- Кazan State Medical University, Kazan
- Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan, Kazan
- Issue: Vol 7, No 3 (2012)
- Pages: 34-36
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121572
- DOI: https://doi.org/10.23868/gc121572
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Full Text
Abstract
should be made on the basis of morphological analysis of
liver biopsies. The aim of our study was to investigate the
effect of autologous hematopoietic stem cell transplantation
on histology activity index and grade of fibrosis in alcoholic
liver cirrhosis patients. The study was performed on liver
biopsies of 11 patients with alcoholic liver cirrhosis. Biopsies
were taken before the injection of autologous peripheral
blood stem cells into celiac trunk, 3 and 12 months after
the procedure. Liver biopsy specimens were stained with
hematoxylin-eosin and Van Gieson's. Results showed
improvement of liver structure and decrease in histology
activity index in liver biopsies performed 3 and 12 months
after transplantation. Our data suggest that autologous
transplantation of hematopoietic stem cell in patients with
alcoholic liver cirrhosis is effective method that is capable
to reduce inflammation activity in the liver, improve its
structure and decrease liver fibrogenesis.
About the authors
G R Burganova
S R Abdulkhakov
A A Gumerova
I M Gazizov
T S Yylmaz
M A Titova
A Kh Odintsova
A P Kiyasov
G R Burganova
Кazan State Medical University, KazanКazan State Medical University, Kazan
S R Abdulkhakov
Кazan State Medical University, KazanКazan State Medical University, Kazan
A A Gumerova
Кazan State Medical University, KazanКazan State Medical University, Kazan
I M Gazizov
Кazan State Medical University, KazanКazan State Medical University, Kazan
T S Yilmaz
Кazan State Medical University, KazanКazan State Medical University, Kazan
M A Titova
Кazan State Medical University, KazanКazan State Medical University, Kazan
A Kh Odintcova
Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan, KazanRepublican Clinical Hospital, Ministry of Health of the Republic of Tatarstan, Kazan
A P Kiassov
Кazan State Medical University, KazanКazan State Medical University, Kazan
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