Suppression of calcification of heart valve transplants by their devitalization


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Abstract

Suppression of calcinosis and degeneration of heart valve transplants is important aim for improving their durability. It was shown previously that well-known methods of decellularisation including treatments with enzymes or some detergents or with hypotonic solution didn't suppress calcification of implanted aorta. In the present study we showed potential in prevention of calcinosis by a treatment, which induced death of donor cells without their total destruction before implantation. This method of anticalcinosis devitalisation is based on a hypothesis of mechanism of calcinosis initiation in heart valve transplants, which was earllier proposed in our group.

About the authors

V S Akatov

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

N I Fesenko

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

V V Soloviev

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

I S Fadeeva

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

A V Chekanov

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

Institute of Theoretical and Experimental Biophysics of RAS, PushchinoPushchino State University, Pushchino

R M Muratov

Bakulev Center for Cardiovascular Surgery of RAMS, Moscow

Bakulev Center for Cardiovascular Surgery of RAMS, Moscow

D V Britikov

Bakulev Center for Cardiovascular Surgery of RAMS, Moscow

Bakulev Center for Cardiovascular Surgery of RAMS, Moscow

A S Sachkov

Bakulev Center for Cardiovascular Surgery of RAMS, Moscow

Bakulev Center for Cardiovascular Surgery of RAMS, Moscow

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