The use of transplants containing multipotent mesenchymal stromal cells for the repair of the articular surface in experiment



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Abstract

The effects of the allogeneous demineralized bone transplants, seeded with bone marrow-derived multipotent mesenchymal stromal cells CMSCsJ, on the healing of the damaged articular cartilage and the subchondral bone were studied. It was shown that the use of allogeneous as well as autologous MSCs on the demineralized bone transplants and also on the transplants combined with type I collagen gel promote the remodeling of the regenerating tissue and the recovery of the histotypic cartilaginous and osseous structures in comparison with the articular surface regeneration without any therapy or after the procedure of the mosaic chondroplasty. Nevertheless, the positive effects of cell therapy were not clinically prominent, which means most probably in that case that the generally accepted experimental model is not adequate in full measure, but the approach used is promising.

About the authors

A S Grigoryan

R V Deev

P V Kruglyakov

A A Bilibina

I B Sokolova

N N Pavlichenko

D G Polyntsev

A S Grigorian

Trans-Technologies Ltd., Saint-Petersburg

Trans-Technologies Ltd., Saint-Petersburg

R V Deev

R.R.Wreden Russian Institute of Traumatology and Orthopedics, Saint PetersburgHuman Stem Cells Institute, Ltd. Moscow

R.R.Wreden Russian Institute of Traumatology and Orthopedics, Saint PetersburgHuman Stem Cells Institute, Ltd. Moscow

P V Kruglyakov

Trans-Technologies Ltd., Saint-Petersburg

Trans-Technologies Ltd., Saint-Petersburg

A A Bilibina

Trans-Technologies Ltd., Saint-Petersburg

Trans-Technologies Ltd., Saint-Petersburg

I B Sokolova

Trans-Technologies Ltd., Saint-Petersburg

Trans-Technologies Ltd., Saint-Petersburg

N N Pavlichenko

Trans-Technologies Ltd., Saint-Petersburg

Trans-Technologies Ltd., Saint-Petersburg

D G Polyntsev

Trans-Technologies Ltd., Saint-Petersburg

Trans-Technologies Ltd., Saint-Petersburg

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