Directed myogenic reprogramming of differentiated cells

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A morphological manifestation of myopathies is progressive lesion of muscular tissue with it substitution by connective tissue which makes it necessary to compensate cell loss. To date, methods which can replenish a cell pool in an affected muscle are absent. A method which potentially can correct manifestations of such diseases is a direct cell reprogramming. The undoubted advantage of this approach is an absence of necessity of returning cell in a pluripotent stage which allows to use it in vivo. The great experience in myogenic conversion was accumulated since discovering this method in 1987 by R.L. Davis and H.M. Weintraub. This review is aimed to describe the fundamental bases of direct cell reprogramming, it's positioning in the system of cell fate routes, analysis of achievements in direct cell reprogramming field and discussion about unsolved issues.

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About the authors

F. A Indeikin

Kazan State Medical University


M. O Mavlikeev

Kazan (Volga region) Federal University

R. V Deev

PJSC «Human Stem Cells Institute»; I.P. Pavlov Ryazan State Medical University


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