Regenerative technologies in treatment of diabetic foot ulcers



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Abstract

Regenerative medicine is one of the new fast growing approaches to the treatment of a variety of diseases, including oncology and cardiovascular pathology, degenerative-dystrophic diseases of bones and joints, and other complex diseases including diabetes mellitus. Diabetes is regarded as one of the most dangerous non-infectious diseases in the world with a rising incidence that reaches pandemic proportions. Treatment of patients with diabetic foot ulcers including those with peripheral arterial disease is a challenging issue due to the increased risks for poor and lethal outcomes, which makes the social and economic burden of diabetes mellitus very high. The article presents state-of-the-art regenerative technologies in treatment of diabetic foot ulcers. Special attention is paid to gene and cell therapy.

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About the authors

R. E Kalinin

I.P. Pavlov Ryazan State Medical University

Ryazan, Russia

I. A Suchkov

I.P. Pavlov Ryazan State Medical University

Ryazan, Russia

N. D Mzhavanadze

I.P. Pavlov Ryazan State Medical University

Ryazan, Russia

A. A Krylov

I.P. Pavlov Ryazan State Medical University

Ryazan, Russia

A. A Isaev

Human Stem Cell Institute

Moscow, Russia

I. L Plaksa

Human Stem Cell Institute

Moscow, Russia

R. V Deev

I.P. Pavlov Ryazan State Medical University; Human Stem Cell Institute

Moscow,Ryazan, Russia

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