Antitumor effect of hybrid nanocomplexes containing nanoparticles of orthovanadates rare earth elements and cholesterol
- Authors: Goltsev A.N1, Babenko N.N1, Gaevskaya Y.A1, Chelombytko O.V1, Bondarovich N.A1, Dubrava T.G1, Ostankov M.V1, Dimitrov A.Y.1, Klochkov V.K2, Kavok N.S2, Malyukin Y.V2
-
Affiliations:
- Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
- Institute for Scintillation Materials of the NAS of Ukraine
- Issue: Vol 10, No 2 (2015)
- Pages: 54-60
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/120489
- DOI: https://doi.org/10.23868/gc120489
- ID: 120489
Cite item
Abstract
Full Text

About the authors
A. N Goltsev
Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
N. N Babenko
Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
Yu. A Gaevskaya
Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
O. V Chelombytko
Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
N. A Bondarovich
Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
T. G Dubrava
Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
M. V Ostankov
Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
A. Yu Dimitrov
Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine
V. K Klochkov
Institute for Scintillation Materials of the NAS of Ukraine
N. S Kavok
Institute for Scintillation Materials of the NAS of Ukraine
Yu. V Malyukin
Institute for Scintillation Materials of the NAS of Ukraine
References
- Ambasta R.K., Sharma A., Kumar P. Nanoparticle mediated targeting of VEGFR and cancer stem cells for cancer therapy Vasc Cell. 2011; 3: 26.
- Evangelou A.M. Vanadium in cancer treatment. Crit. Rev. 0ncol. Hematol. 2002; 42 (3): 249-65.
- Kopf-Maier P, Krahl D. Tumor inhibition by metallocenes: ultrastructural localisationof titanium and vanadium, in treated tumor cells by electron energy loss spectroscopy. Chem. Biol. interact. 1983; 44(3): 317-28.
- Клочков В.К. Інститут сцинтиляційних матеріалів НАН України, власник. Спосі6 отримання водної дисперсії холестерину. Патент Украины 10801. 10. 03. 2015.
- Al - Jarallah A., Trigatti B.L. A role for the scavenger receptor, class B type i in high density lipoprotein dependent activation of cellular signaling pathways. Biochim Biophys Acta. 2010; 1801(12): 1239-48.
- Гольцев А.Н., Бабенко Н.Н., Гаевская Ю.А. и др. Идентификация опухолевых клеток гибридными комплексами на основе неорганических наночастиц и органических биологически активных соединений. Сб. статей 16-й Междунар. научн.-практ. конференции «Фундаментальные и прикладные исследования, разработка и применение высоких технологий в промышленности и экономике», 5-6 декабря 2013 г., СПб.: Изд-во Политех. ун-та, 2013. С. 121-31.
- Ozaslan M., Karagoz I.D., Kilic I.H. et al. Ehrlich ascites carcinoma. African J. Biotech. 2011; 10(13): 2375-78.
- Al-Hajj M., Wicha M.S., Benito-Hernandez A. et al. Prospective identification of tumorigenic breast cancer cells. PNAS USA 2003; 100 (7): 3983-8.
- Ponti D., Costa A., Zaffaroni N. et al. isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 2005; 65: 5506-11.
- Jaggupilli A., Elkord E. Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity. Clin. Dev. immunol. 2012; 2012: 708036.
- Ghebeh H., Sleiman G.M., Manogaran P.S. et al. Profiling of normal and malignant breast tissue show CD44high/CD24low phenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers. BMC Cancer 2013; 13: 289
- Chaffer C.L., Brueckmann I., Scheel C. et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. PNAS USA 2011; 108: 7950-5.
- Goltsev A.N., Chelombytko O.V., Bondarovich N.A. et al. Cryopreservation effect on pluripotency gene expression in Ehrlich carcinoma cells cells: Abstracts of Annual Scientific Conference & AGM of the Society for Low Temperature Biology (STBL) «Freezing biological time 50th Anniversary Celebration» London, UK, October 8-10, 2014. P. 84.
- Shipitsin M., Campbell L.L., Argani P., et al. Molecular definition of breast tumor heterogeneity Cancer Cell 2007; 11: 259-73
- Ezeh U.I., Turek P.J., Reijo R.A. et al. Human embryonic stem cell genes 0CT4, NAN0G, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 2005; 104: 2255-65.
- Kumar S.M., Liu S., Lu H. et al. Acquired cancer stem cell phenotypes through 0ct4-mediated dedifferentiation. Oncogene 2012; 31: 4898-911.
- Wang M.L., Chiou S.H., Wu C.W. Targeting cancer stem cells: emerging role of Nanog transcription factor 0nco Targets Ther 2013; 4 (6): 1207-20.
- Гольцев А.М., Сафранчук О.В., Бондарович М.О. та інш. Мєтодичні підходи до стабілізації структурного і функціонального станів кріоконсервованих клітин аденокарциноми Ерліха. Доповіді Національної академії наук України. 2012; (8): 115-22.
- Клочков В.К. Водные коллоидные растворы нанолюминофоров nReV04:Eu3+ (Re = Y, Gd, La). Наноструктурное материаловедение 2009; (2): 3-8
- Livak K.J., Schmittgen Th.D. Analysis of relative gene expression data Using real-time quantitative PCR and the 2-AACt method. Methods 2001; 25: 402-8.
- Betker J.L., Kullberg M., Gomez J. et al. Cholesterol domains enhance transfection. Ther. Deliv. 2013; 4(4): 453-62.
- Гольцев А.Н., Бабенко Н.Н., Гаевская Ю.А. и др. Способность наночастиц на основе ортованадатов к идентификации in vitro и ингибиции in vivo стволовых раковых клеток Наносистемы, наноматериалы, нанотехнологии 2013; 11(4): 729-39.
- Leung E.L., Fiscus R.R., Tung J.W. et al. Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties PLoS 0ne 2010; 19 (5): 11-9.
- Korkaya H., Paulson A., Charafe-Jauffret E. et al. Regulation of mam-mary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol. 2009; 7 (6): 100-21.
- Matsuda S., Nakanishi A., Wada Y. et al. Roles of Pi3K/AKT/ PTEN Pathway as a target for pharmaceutical therapy 0pen Med Chem. J. 2013; 7: 23-9.
- Cooper D.L., Dougherty G.J. To metastasize or not - selection of CD44 splice sites Nat Med 1995; 1: 95-7
- Williams D.A., Cancelas J. A. Leukaemia: niche retreats for stem cells. Nature 2006; 444(7121): 827-8.
- Bourguignon L.Y.W., Peyrollier K., Xia W. et al. Hyaluronan-CD44 interaction activates stem cell marker nanog, stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J. Biol. Chem. 2008; 283(25): 17635-51.
