The role of EF-hand Са2+/Mg2+-binding tescalcin protein in cell proliferation and differentiation


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Abstract

EF-hand Са2+/Мд2+-binding proteins are involved in many important processes in the body. Identification and analysis of the EF-hand motifs in the genome led to the discovery of novel Ca2+-binding proteins, which are potentially useful for biomedical applications. One of such molecules is tescalcin - 24 kDa protein with one EF-hand motif. Tescalcin plays an important role in differentiation of hematopoietic cells by regulating the expression of Ets family transcription factors via PMA-induced ERK-pathway. At the molecular level, it was shown to interact with subunit 4 of signalosome COP9 and Na+/H+-exchanger. Recently a potential use of tescalcin for cancer diagnostics was demonstrated

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About the authors

K. G Kolobynina

Kazan (Volga Region) Federal University

V. V Solovyeva

Kazan (Volga Region) Federal University

V. Z Slepak

University of Miami Miller School of Medicine

A. A Rizvanov

Kazan (Volga Region) Federal University

Email: Albert.Rizvanov@kpfu.ru

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