The role of EF-hand Са2+/Mg2+-binding tescalcin protein in cell proliferation and differentiation
- Authors: Kolobynina K.G1, Solovyeva V.V1, Slepak V.Z2, Rizvanov A.A1
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Affiliations:
- Kazan (Volga Region) Federal University
- University of Miami Miller School of Medicine
- Issue: Vol 10, No 1 (2015)
- Pages: 28-34
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/120459
- DOI: https://doi.org/10.23868/gc120459
- ID: 120459
Cite item
Abstract
EF-hand Са2+/Мд2+-binding proteins are involved in many important processes in the body. Identification and analysis of the EF-hand motifs in the genome led to the discovery of novel Ca2+-binding proteins, which are potentially useful for biomedical applications. One of such molecules is tescalcin - 24 kDa protein with one EF-hand motif. Tescalcin plays an important role in differentiation of hematopoietic cells by regulating the expression of Ets family transcription factors via PMA-induced ERK-pathway. At the molecular level, it was shown to interact with subunit 4 of signalosome COP9 and Na+/H+-exchanger. Recently a potential use of tescalcin for cancer diagnostics was demonstrated
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About the authors
K. G Kolobynina
Kazan (Volga Region) Federal University
V. V Solovyeva
Kazan (Volga Region) Federal University
V. Z Slepak
University of Miami Miller School of Medicine
A. A Rizvanov
Kazan (Volga Region) Federal University
Email: Albert.Rizvanov@kpfu.ru
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