Influence of liver perisinusoidal cell transplantation on liver regeneration after damage induced by CCL4 and 2-acetylaminofluorene


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Abstract

Research in the past decade allows us to consider liver perisinusoidal cells as a possible regional stem cells of the liver. Despite of this, there is no work dedicated to study their influence to liver regeneration. The aim of this work was to study liver regeneration after liver perisinusoidal cell transplantation in rats with CCL4 and combination of CCL4 and 2-acetylaminofluorene damage. Our results showed that in both models of toxic damage transplanted perisinusoidal cells are found in the recipient's liver and exhibit the properties of stem cells by differentiation into hepatocytes. Transdifferentiation of injected cells into myofibroblasts was not detected which indicates the absence of liver fibrosis risk after use of this cell type for cell therapy.

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About the authors

G. R Burganova

Kazan (Volga region) Federal University

A. A Titova

Kazan (Volga region) Federal University

E. I Sharipova

Kazan (Volga region) Federal University; Kazan State Medical University

G. O Pevnev

Kazan (Volga region) Federal University; Kazan State Medical University

M. O Mavlikeev

Kazan (Volga region) Federal University

I. M Gazizov

Kazan (Volga region) Federal University; Kazan State Medical University

A. R Galyavieva

Kazan State Medical University

A. K Shafigullina

Kazan (Volga region) Federal University

M. S Kaligin

Kazan (Volga region) Federal University

M. A Titova

Kazan (Volga region) Federal University

A. A Gumerova

Kazan (Volga region) Federal University

A. P Kiassov

Kazan (Volga region) Federal University

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