The models for the study of biological properties of human hematopoietic stem cells

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  • Authors: Ustyugov A.Y.1, Rumyantsev S.A2
  • Affiliations:
    1. D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, MH of Russia, Moscow, Russia N.I. Pirogov Russian National Research Medical University, MH of Russia, Moscow, Russia
    2. D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, MH of Russia, Moscow, Russia N.I. Pirogov Russian National Research Medical University, MH of Russia, Moscow, Russia Moscow Institute of Physics and Technology (State University), Moscow, Russia
  • Issue: Vol 9, No 1 (2014)
  • Pages: 15-22
  • Section: Articles
  • URL: https://genescells.ru/2313-1829/article/view/120240
  • DOI: https://doi.org/10.23868/gc120240

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Abstract

The article describes different experimental in vivo models applied to achieve knowledge of hemopoiesis and stem cell source-dependent mechanisms of engraftment. Although all the models have relative advantages and drawbacks, they all have one common feature - the cord blood engraftment kinetics are better, than those of bone marrow stem cells, while those are superior to peripheral blood mobilized stem cells. In spite of all the progress achieved by prolonged research, the cause of relatively low level of the human cells generated in these models is still unclear. The solution to this problem may be found with the aid of gene engineering achievements.

About the authors

A. Yu Ustyugov

D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, MH of Russia, Moscow, Russia N.I. Pirogov Russian National Research Medical University, MH of Russia, Moscow, Russia

S. A Rumyantsev

D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, MH of Russia, Moscow, Russia N.I. Pirogov Russian National Research Medical University, MH of Russia, Moscow, Russia Moscow Institute of Physics and Technology (State University), Moscow, Russia

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